Tinker and Alliance are looking pretty shaky in the long term - Tinker just dropped out of a tournament and Alliance was unable to play games of theirs earlier today. It looks right now like they'll soon see major changes, disband, or become one team. Alliance also sponsors a League of Legends team and a few other teams in other scenes though.
EDIT: This also includes D2L - a relatively large DOTA league, as well as parts of CLG (CounterLogic Gaming) - http://clgaming.net/news/611-kelby-may-steps-down-as-general...