HN user

Fede_V

4,422 karma

Researcher. Systems biology, open science, data analysis, machine learning and effective altruism. E-mail: 5a308f7e 'at' opayq.com

Posts30
Comments423
View on HN
news.ycombinator.com 2y ago

Ask HN: What high quality paid (non-subscription) software would you recommend?

Fede_V
2pts1
news.ycombinator.com 5y ago

Ask HN: Non-Subscription Paid Software Recommendations

Fede_V
4pts4
www.insidehighered.com 7y ago

Showdown between Elsevier and UC over paying for publications

Fede_V
2pts1
www.politico.com 8y ago

FCC chairman to push for full repeal of net neutrality

Fede_V
30pts2
qz.com 8y ago

A 2017 Nobel laureate says he left science because he ran out of money

Fede_V
226pts80
www.forbes.com 9y ago

MD Anderson pulls back from collaboration with IBM

Fede_V
2pts0
www.sciencemag.org 9y ago

Duke sued by whistleblower over fraudulent data used to win big grants

Fede_V
2pts0
www.nature.com 9y ago

Ioannidis (Author Of: Most Research Findings Are Wrong) in Running for NIH Head

Fede_V
1pts0
www.newyorker.com 10y ago

Digging for Glory: the discovery of Australopithecus sediba

Fede_V
6pts0
www.youtube.com 10y ago

AlphaGo beats Lee Sedol 3-0 [video]

Fede_V
566pts407
mobile.nytimes.com 10y ago

On the proliferation of ninjas, evangelists, and hackers

Fede_V
2pts0
www.geek.com 10y ago

Uber, but for cancelling Comcast subscriptions

Fede_V
1pts0
www.facebook.com 10y ago

“This week, I resigned from my position at Duke University”

Fede_V
279pts133
america.aljazeera.com 10y ago

Ioannidis discusses the lack of meritocracy in Greece

Fede_V
1pts0
elifesciences.org 11y ago

The number of olfactory stimuli that humans can discriminate is still unknown

Fede_V
9pts3
arxiv.org 11y ago

Alan Turing: The Applications of Probability to Cryptography [pdf]

Fede_V
47pts3
www.economist.com 11y ago

The Economist on how to join the global elite

Fede_V
1pts0
slatestarcodex.com 11y ago

Gender and Academia Redux: Researcher Bias Is a Big Deal

Fede_V
1pts0
elifesciences.org 11y ago

Living science: Triaging Shakespeare

Fede_V
1pts0
www.jpl.nasa.gov 11y ago

'Bright Spot' on Ceres Has Dimmer Companion

Fede_V
14pts0
chronicle.com 11y ago

Can The Human Brain Project be saved, and should it be?

Fede_V
108pts81
jobs.timeshighereducation.co.uk 11y ago

Bristol University Seeks 'Associate Dean of Eureka Moments'

Fede_V
1pts0
www.cancerletter.com 11y ago

Duke Officials Silenced Med Student Who Reported Trouble in Anil Potti's Lab

Fede_V
261pts55
github.com 11y ago

Regexp-based DMCA takedowns claim another victim

Fede_V
3pts0
bjoern.brembs.net 11y ago

The Growth of Administrative Staff in Universities

Fede_V
137pts90
liorpachter.wordpress.com 11y ago

The two cultures of mathematics and biology

Fede_V
126pts69
arstechnica.com 11y ago

Spanish publishers move to halt Google News closure

Fede_V
3pts1
www.worldbulletin.net 11y ago

Spain wants Google News back

Fede_V
2pts0
blogs.hbr.org 12y ago

Graph theory applied to conferences

Fede_V
1pts0
starryskyaboveme.wordpress.com 12y ago

What would change your mind?

Fede_V
1pts0

The fast.ai courses are exceptionally good for getting started and learning the concepts, but, once you've mastered an intuitive understanding of the techniques, I highly encourage people to dig deeper into the concepts - specifically, reverse SDEs, stochastic calculus, optimization, score matching.

Jeremy does an excellent job making the content approachable, but, if you want to go beyond being an excellent practicioner, you cannot skip the theory bits.

It's a vicious cycle, but, every time one of these internal town halls gets leaked to the internet, the execs lose the ability to speak candidly, and the workers feel like execs are completely aloof and detached from the reality on the ground.

Unfortunately, it's incredibly difficult to maintain a certain level of trust once an org gets over a certain size.

I absolutely think that depositors should be made whole - and - they will.

At the same time, I think a lot of the VCs who systematically talked shit about government regulations while trying to shill crypto as a solution should very publicly eat crow. I won't lie: it will give me a great deal of personal satisfaction, but, it will also make any "bailout" (or, whatever you want to call it ) a much easier lift politically.

Absolutely: the challenge is that any signal that you use to identify "good websites" from "bad websites" will be adversarially optimized by incredibly motivated people.

You are dealing with a moving target that has a huge financial incentive. It's a very difficult problem.

I distinctly remember a prescient thread from Yishan Wong (former Reddit CEO) about how trying to run Twitter would break Musk - and - it looks like it was spot on.

He paid 44 billion dollars to be a mod - I hope he is getting his money's worth.

Beyond the criticism of the format, I found the explicit clout chasing to be completely offputting, and I think I used Clubhouse a grand total of 3x before never turning it on.

I would genuinely love to read an anthropologist dive into what causes social networks to take that turn. At its best, Twitter is full of smart nerdy people talking about science, mathematics, history, etc..

Clubhouse feels like LinkedIn, completely detached from resumes, so everyone wanted to post thinkpieces without being in any way tethered to their concrete achievements.

I wish this was on the GoodNotes/SublimeText model: pay once for a premium version of the app, and then never worry about subscriptions. The moment something requires subscription my threshold for buying it goes up 1000 fold.

I know that Apple is incredibly secretive about their launches, and I'm not surprised that carries over to their internal culture, but, I'm incredibly skeptical of stories told from the point of view of an HR person that has every single incentive to hype up their revolutionary new process that unleashed productivity and improved morale.

Every single time I read a similar story and I had first or second hand knowledge of how things actually played out, the role of the person telling the story was massively stretched out.

I agree with your first point: 24 out of 394 is too many for my taste, but, given how hyped the sector is, it’s not a huge amount.

Per the second point, I actually completely disagree. I think there’s huge social dynamics in play that make it harder to move away from proof of work because miners have massive amounts invested into mining equipment. We might see Ethereum move to PoS eventually (maybe) - but - that will be in spite of social dynamics and because some of the leaders are stubbornly trying to do the right thing.

What a disappointment, so many NFT/crypto companies. Given current blockchain technology, this is something that straight up makes the world a worse place by making existing processes significantly more carbon intensive.

I would consider working in crypto to be the equivalent of working for Juul or a tobacco company. Not quite as evil as working for a company that provides spyware that's used against human rights activists, but, the rung above that.

I'm a bit torn: I see the potential for civil liberties abuse, but, one of the things I loathe the most about American culture is how entitled 'consumers' feel towards treating workers that are serving them. I feel that the mistreatment of airport staff is that kind of behaviour taken to extremes- and it's something I'd like to see utterly crushed.

I think the complaints about SEO spam are valid - but - I think msweibel and pg misdiagnose the challenge. The challenge is that you are dealing with an adversarial system, and, the better your search engine is, the more widely used it becomes, the more valuable it is for your adversaries to find ways to game your rankings.

Any new niche search engine will go through a small window of time where they have the luxury that none of the sites they are indexing are spending all their effort trying to reverse engineer your signals, and optimize against them. I'm incredibly skeptical that they can remain useful once people all the SEO efforts of various marketers start to be turned against them.

Reading that story, I wonder where hustle culture went wrong. Paul Graham famously celebrated "breaking the rules" (http://www.paulgraham.com/founders.html) - but - this is a crazy ratchet.

I really hope that this behaviour doesn't become any more normalized than it already has. Success is not worth anything, and, while some rules may be pointless, not every rule (and norm) is an obstacle you have to hack around on your way to success.

That's exactly right. I've seen zero products where the blockchain is a compelling value ad, with the exception of:

- it makes it easier to raise capital by claiming that what you are doing involves crypto, because then you get crypto-type valuations

- you can get money from people who want to speculate

I'm a bit confused: Google Stadia (and the Amazon/Nvidia) HN has a deserved reputation for missing the obvious value add of a service, so I'd like people to correct me but - isn't this basically Stadia, except it costs 5x as much, and you can only "play" Chrome?

I've been reading a few of the white papers about this, but I'd absolutely love to go deeper in this. Do you have any suggestions?

I am especially interested in assessment about CO2 emissions from credible sources (please, no VCs with zero training in physical sciences posting thought leadership pieces, I beg you).

We should do a much better job of building energy efficient devices, but, the amount of energy that's "wasted" by things like TVs that never turned off is really tiny compared to the energy footprint of the crypto ecosystem.

Further, I worry that crypto will grow massively. If that happens, all bets are off. In its current state, crypto consumes more energy than several large countries - imagine a world where that's 10x or 100x and we've still not moved off of proof of work. What's global warming going to look like?

I'm horrendously worried about crypto gaining more marketshare as long as proof of work crypto remains mainstream. It has significantly worse externalities than just about any company I can think of (including defense contractors/vaping companies), and, if it grows larger before we have clean energy, then we virtually guarantee we won't be able to tackle global warming. We are going to bestow a world that will be significantly worse than the one we inherited to our children, and, it's not like the carbon emissions that crypto is creating are used in the service of creating valuable technology - it's literally useless proof of work.

I've worked in tech for a long time now, and I believe the stereotype about amoral techies is completely untrue - yet seeing the adoption of crypto among my peers is really depressing. I'm not sure how so many of my peers who would never ever work for a defense contractor or a vaping company are willing to work in crypto at this point. My objections are not ideological - if someone invented a cryptocurrency that was completely green and it would take over the market, I'd be totally in favor of it.

I would genuinely like someone to explain it to me, because, the kinds of essays I've read that try to argue that crypto is actually good for global warming are so shoddy that I can't believe people would take them seriously absent a huge dose of motivated reasoning.

I had a chance to speak to Marino when he came to give a talk about bioethics at my PhD institution. He was a very smart man - but he made several mistakes.

For example - he made up a ridiculous story about being invited by the pope to attend a march in Philadelphia, which quickly got exposed as a lie. He was also completely unable to handle the local Roman political players / senior civil servants (who, granted, are hideously corrupt and have been running things for their own self dealings with left governments, center governments, far right governments, and 5 star governments (whatever they are)).

A couple of years later - Thatcher had a similar confrontation with the miners striking against the government in the UK. Note that miner strikes had taken down the previous government and obtained a lot of concessions - so the Thatcher government was actually prepared and had stockpiled coal / prepared a PR campaign for when the strike would actually take place.

Whenever I read something this far off the mark, I genuinely wonder if it's total lack of intellectual honesty, or, having drank so much kool aid that this argument genuinely makes sense.

Bitcoin transactions require the solution of a completely useless and expensive to compute mathematical computation. THIS IS BY DESIGN, TO MAKE IT SCARCE.

In the short term, we are facing a critical shortage of computer chips because bitcoin miners are buying critical infrastructure and using them to do absolutely useless math to speculate on an obvious bubble.

In the long term, we absolutely need to solve global warming, and the only way we will do so is if we figure out a way to decouple carbon emissions from productivity on a global scale. Bitcoin makes this task much harder - by its very definition, bitcoin literally scales with energy consumption. Energy prices and bitcoin prices (plus fixed costs due to mining equipment) will always be in some sort of equilibrium. Second - we need those chips that are currently calculating completely useless hashes to actually be put to use in productive sectors.

IF your attitude is some variant of - fuck you, I don't care about the world, I just want to get rich profiting from this bubble - fine, I can't convince you to care about the rest of humanity. But please - be clear eyed about this: there is not a single credible global warming scholar that believes Bitcoin will help. Not one. The only people who try to push forward incredibly shoddy thinkpieces about how Bitcoin/NFTs will help global warming are obviously Bitcoin speculators or paid shills.

I think that requiring politicians to make public their statements explaining their the decisions on behalf of their constituents would be and unalloyed public good

Sure, this is fine, but that's very different from requiring all their interactions to be public. Put it this this: how often do you ever hear anything insightful or intelligent in a public congressional/senate hearing? It's always politicians trying to ask really stupid gotcha questions that will make them look good to the audience at home.