AnthonBerg

There's the very nice precedent of using "we" in academic literature. You wrote that piece well. (You singular wrote we plural?, haha)

Belated!

Been thinking about this since… 6 days ago!, haha

and! This:

"Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor"

https://www.pnas.org/doi/10.1073/pnas.0603119103

(We are all coated in urocanic acid. Right now. We secrete it. ahhaha. what!! And. It isomerizes in UV light and plops into the 5-HT2A receptor and downregulates inflammation.)

Good question!! thank you!

Because of this paper: https://www.frontiersin.org/journals/behavioral-neuroscience...

(and having had twice the experience of autoimmune related illnesses making people close to me very aggressive until diagnosed and treated; and it was 1:1 always with things that made inflammation go up, aggression went up. In retrospect. And the opposite: things that reduced aggression always have an inflammation-reducing aspect)

All of the "surprising" stuff they do is because they reduce neuroinflammation. Imo. As far as I can tell from the literature.

I'm fairly sure that part of the reason they reduce neuroinflammation is because of pulmonary GLP-1 mechanisms. (Lung and brain are quite intimately connected, as is inflammation to the other two. As well as the gut. And… metabolism.)

Neuroinflammation is very behavior-modifying.

(Neuroinflammation kind of makes sense as an untamperable side-channel of information for neuronal processes – out of band; Protective. Can't think yourself to death.)

There's tons of papers to read. You wouldn't believe how much accurate and correct and actionable and predictive scientific information exists that nobody reads.

Read primary sources. Anyone can read. Don't let anyone tell you that you can't read. Least of all yourself.

dB?

Or! a "handheld gaming" device that runs mainline Linux.

Setting aside what they're for, Linux handheld gaming devices are kind of a perfect fit for a minor "house computer". Made cheap by commodification. Flexible. Sadly no GPIO in these I think but tack on an RP2350 and we're golden.

Strip or modify the chassis and embed them hidden or with the screen facing out. Kachinng.

Hard to pin into words!

We're unconscious of how unconscious we are?, and it's good to… what's the term, suffer gladly and give gladly? To own one's unconsciousness and raise it, and expect and see others' unconscious going about major things in life - to see it coldly as well as warmly.

I find this is more accurate and safer than assuming consciousness in everyone, and it also reveals so clearly people who do cast that light; and see.

It's less desolate! I promise! Sounds like it's worse but it's not. That's the tricky-get-into-words part, you know?

I have no conscious awareness of what I wrote, I just tried to be Peter Wattsy, haha

(kidding!

It's oversold, or beautiful artistic expression of something. Bleak, yes; Stark; Also beautiful.

The thing it expresses is… a thing. We're not at all as conscious as… we think?, as we portray ourselves?, to others and/or ourselves? And it's magical to view people as… partially unconscious to a significant degree while also loving them and with respect.)

I see people differently after reading Blindsight; The picture is much darker, concretely more accurate, with what light is there geared to all hell and so much brighter. I'm better for it and at a greater peace.

My sincere apologies!

I was misreading due to — I think noticeable — negativity in other comments.

I expect to better be able to port the Cherry MX ULP board and choose to call it portable

I just have to say… The comments in this HN thread are The Worst. Judgy and weird and missing the point. Splash is fun and cool.

"I AM genuinely glad this person is having fun with the little world they’re creating, and that they’re bothering to share it."

What's with the ridiculous condescension?

I'm also glad that little person you typed your little comments with your fingers! That you created such a fun little comment! And that you shared it with us. Wowie! Good job.

This is quite the unhinged and accusatory attempt at uncalled-for dismissal. What's with the attack?

Feedback is when it's useful.

Haha yes! Psychiatric medication, that purely abstract pill that does not affect the physical body in any way, only enters the mind!

—

Serotonin is among other things a nausea and thermoregulation neurotransmitter, and has to do with cognition. Most serotonin in the body is synthesized in the gut – a highly enervated endothelial membrane – transported by platelets, and metabolized in the lung.

SARS-CoV-2 is known to damage endothelium, known to cause really weird platelet and blood clotting issues like platelet necroptosis and infection and alteration of bone marrow platelet progenitor cells, known to cause lung injury. In a whole bunch of ways.

Anthropomorphization is just such a sexy, attractive guy. So seductive. I always give in to what he wants…

Yes!

The other half of self-interest in being nice is the training and getting better at it.

M… maybe… because he transiently accumulated 3% greater zeroeth-derivative value every time he first-derivatived along an orthogonal axis.

Stalled project: I ordered a replacement keyboard for an Alienware gaming laptop, one that has Cherry MX ULP ultralow profile switches. Very very nice. Then I was going to butcher it into a triptych – cut it in three parts – and bodge a RP2350 controller on each. And figure out some kind of case-something. Tadaa! Actual keyboard – real keyboard – that's actually portable.

I swear: Good JVM settings can make Jetbrains IDEs fly with performance. Startup is way faster too.

I like ZGC. And having the IDE grab more RAM immediately on startup than the default. Something like Xms=4g or however it's done.

I cannot understand why Jetbrains keep the VM settings as constrained as they do. It's a big difference.

I see myself.

I was quite surprised to find that paper! Thank you for… the audience?, for your consideration? It's quietly somewhat maddening that this is on the books and there's so little mention of it.

Like, psychedelics? I'm not a hippie. I'm not into psychedelics. I'm into neuroinflammation, haha

Nothing and everything: https://www.frontiersin.org/journals/immunology/articles/10....

(This is a serious article by a serious researcher. There exists good work on Frontiers in….)

The 5-HT2A receptor is profoundly immunomodulatory. (Acid is arguably a more potent immunomodulator – an antiinflammatory one – than it is psychoactive.) Local inflammation is a thing in injury, "global" inflammation as well – there is strong interplay between cytokines and metabolic/anabolic/catabolic process; Interleukin-6 stimulates osteoclasts which actively break down joint tissue – and neuroinflammation also affects physiology. Muscle tone, blood flow, pulmonary function, and so on.

Ego death happens to be a phenomenon or qualia when you boop that receptor hard. I'm not sure ego death necessary for anything. It might be. Ego death is very intimately related to the individual neuronal state and memory, and inflammation is quite enmeshed with that. (Cf. cortisol.)

Inwardly my emotions became numb. I was disconnected from others emotionally. Outwardly my entire vibe shifted from chill to aggressive. I became more argumentative at home. I was looking to dominate others in my interactions.

This is neuroinflammation. This is a way how neuroinflammation presents.

This is as dangerous as people talking together on e.g. Facebook groups. I've seen people give flat out dangerous advice, and other people take it.

Nursed someone back to health and went through a T1D pregnancy and certainly had to work with the clinicians during; Desperately: There is use for this software, and no greater need to bury it or unmake it than it is to bury or unmake Facebook groups or other discussion venues.

In fact, software that actually reads literature and presents perspectives actually derived from plausibility from a scientific basis is in many cases a 100% increase of availability of such a perspective. Doctors – from experience – may not offer that. And forum lore rarely does.

Software that actually reaches into literature – which LLMs do – and presents its perspective with the required framing is arguably a strict improvement to the infohazardous environment of a given patient with a difficult condition like T1 diabetes.

And I ask for this discussion's participants' understanding of the sarcastically wry use of "basic adult competence". It was at once arrogant and caring, and put forward… in something as quasi-serious as a HN discussion. I think that's OK.

I ask for your understanding in that I chose to have "baseline adult competence" highly load-bearing in my comment. This does not include people who have only such poor judgement to guide them that they use Facebook posts as input to managing their T1D pump/sensor-based management.

It is entirely possible to beneficially and safely use software like the that which is the topic of the post.

Don't trust the thing. That's not what it's for.

Don't do as I say. I'm just a rando from the Internet.

Don't do as the author of the posted software does. Don't do what the software tells you either. But the software can certainly build an informative perspective and suggest patterns and movements in an exquisitely complex disease. Managing T1D with a pump is exhausting.

Second, re. "your perspective is solely based on recent trauma so I don't know if it is more reliable in any capacity"

This kind of statement is far beyond anything bounded by the self-respect of a balanced adult. What the fuck, and who are you?

My ex-fiancée almost died in 2020. We lost an unborn child in IVF due to grave neglect on behalf of healthcare who missed the glaringly obvious Type 1 diabetes she had; They never once checked her blood sugar. You know what I did? I read the literature. I read medicine, I read molecular biology, I read neuroimmunobiology, I read about the placenta and fetal development.

I stood by my fiancée and carried her by hand back to health. She recovered faster than the endocrinologists expected. Her pregnancy was exemplary, fullly intact placental vitals out to 38.5 weeks. Healthcare is in such a bad state that I was forced to interject and argue coolly and adamantly with doctors on several occasions about potentially severe mistakes they were about to make. EVERY SINGLE TIME when I interceded, it was confirmed correct by a second opinion from a senior doctor.

I don't come here speaking from trauma. I come here speaking from grim and serious and confirmed lived experience of stepping in and caring, without any margin for error. Know how you do that? With extreme humility and the utmost care.

Who are you to speak to me like that; I can tell that you know not at all who I am or what I have been tasked with in this life, because then you would not. talk. to me. this way. Okay?

Type 1 diabetes with the sensors and pump technology that this software being presented here fits to is not Everyman Joe stuff. Someone who can set this up and get this going is already burdened with the kind of analysis that the app can assist with.

"Baseline adult competence" was load-bearing there.

This is not an app for the general public.