Amygaz

I am the US Northeast and the proposal is to move to join the Atlantic standard time and not have DST. Season-wise and Lifestyle-wise, a study concluded that this would be a better fit than the current condition. I’d personally love that.

I don’t disagree that the transition part is the worst, but more people are supporting standard time because it fits better with the schedule of most people.

I used to be on the DST camp, but a few years with a family and house of my own, and suddenly ST makes more sense. Then playing the game of placing oneself into somebody else’s shoes, and I realized that only young adults in rich countries really benefit from DST.

You don't do sustainable farming for the money. It can certainly pay the bills and some. Plus subsidies and incentives can help.

If you want to make money you start a vertical farming AgTech, which will not be profitable, but will attract the trendy funding. Pay yourself well while it last.

Lots of statistic. Especially anything to do with clustering, and how to analyze and compare gene and protein expression networks from various species, or tissues. Those are particularly important in this COVID-19 era.

In term of general network analysis and visualization, I think logic, symbolism, Petri net, are underutilized. Probably because they require more CS and Math type of trained people to work on those than your typical biologist becoming bioinformatician learned to handle.

Leting gouging happens also produces shortages, hoarding, mis-allocation, and crime. And no one starts producing new gas. Gas companies where not the one gouging to begin with, individuals profiteering from an unfortunate and temporary event were.

Any examples?

The main thing we see are individuals hoarding a product, setting up a shop to profiteer from an unfortunate and temporary event.

The situation is temporary and it would be a lousy business model to start developing a "new" product based on the possibility of asking a high price for a short period of time. The incumbents increase in revenue comes from additional number of sales, not from the price hike. What happens when the demand surge goes down? Who is more likely to stay?

I think a government should be able to provide strict guidelines on how a business can comply and get approved for staying open. Some States have that in place for companies that are on the list of exempt businesses, and those lists can be ridiculously long, with plenty of not-essential-at-all businesses.

The current problem is a lack of clear guidelines. To me it seems that the plan is to not have one.

Now, I do condone Musk's. I think his 9yo tantrum throwing behavior is on par with the child king staying at the WH.

Wow. What an answer. All flaviviruses cause ADE. Only few attenuated vaccines worked as a strategy. And no they don't shed.

Thanks for saying that. It is super flawed.

I was planning to go through all of his replies to other posters and debunk them one-by-one.

His assumption is based on live-attenuated vaccines. The measles vaccine being one of those. All the early vaccines where like that. The process only requires heat inactivation. So you end up with a dead or almost dead virus, which can't replicate anymore. Your immune system recognizes it as a foreign agent, makes antibodies to tag it for removal.

Today we prefer to immunize with a part of the virus structure, which end up doing the same thing.

What about Dengue?

So, it that motherjones.com article you link, it's clearly BPA they are talking about, an additive to plastic, not plastic itself.

This is highly opinionated, since I don't know Greg Wyler at all, but I do remember his Terracom broadband satellite effort in Rwanda, which looked noble at first, but was more a pretext to pay himself a generous salary, than doing anything.

So when he started OneWeb and then Ob3 (or vice-versa) I was skeptical. Now, reading about OW, and how it was mostly a middleman, I would say I am not surprised at all that he would pull this one and blame a virus. With chapter 11 he gets to protect his equity and compensation

I expect him to rebound, with even better compensation.

You are OverBallooning what he just said (sorry couldn't resist). There is no implication that the system is absolutely deterministic or will ever be.

Imagine a normal symmetric binomial distribution, along a X-axis of events and severity. Now imagine that the binomial distribution isn't normal and symmetric anymore, it is skewed toward the X-axis of more severe events (i.e. a negative skew). In this model, we still have the same number of events, but their distribution along the severity axis is skewed towards more severe events, and as such they have a higher probability of happening.

I also find this weirdly dubious, but not impossible. I do know that to study human coronavirus in mice, we had to create a mouse line expressing the human ACE2 protein.

I just did a quick protein alignment and the %sequence identity between human and select animals are:

Bats: 81.5% Mice: 81.9% Dogs: 84.1% Cats: 85.2%

And 1.8 billion people in stay-at-home mode, but you may not think this may have anything to do with it.

Did you simply just woke up and decided to troll?

What are you talking about? Louisiana as a over a 1100 cases and they went in shutdown mode yesterday!

The whole thing about warmer region being less infected is still very much controversial, and not backed by any strong science.

India, like other warmer regions, has not been very active in the diagnostic. This is also what explains the low numbers you in Africa, Middle-East, and part of Asia.

Right now there is only one way that we currently have to stop this, and it is to do it Wuhan-style. Full lockdown for 8 weeks.

And forget about chloroquinone, studies published over the past 2 days are showing that it doesn't make a dent if you are already infected.

It's too early to say that. But if they do lift it next week like Trump is trumpeting, then it will.

It's not a question of cost at this point. It's a question of availability of reagents and consumables, materials to make those, and time it takes to ramp up. The supply chain is like a supertanker.

At first we didn't have enough test, but that ramped up quickly, then we didn't have enough RNA extraction reagent, now we don't have enough swabs, and soon is the collection media that will be missing.

There has been a call for more protective equipement. But as the situation gets worst, beds space, ventilator, and then staff are going to be the bottleneck.

If you google you'll find stories of people helping their local hospital by 3D printing parts for for respirators, and swabs. There's nothing cost effective about that, it's not fast, but it gets the job done. If you were to scale that, you would be competing for the same materials than manufacturers using injection molding or plastic dipping are.

Thanks, except the discussion on this one are more relevant, to what is at stake. The other started pretty quickly on pooping the media.

I don't know why you are being down voted. The risk is for false-negative, but you are right that people might think this is going to clear them.

Even the manufacturer/supplier warns that: "Negative results do not preclude SARS-CoV-2 infection and should not be used as the sole basis for patient management decisions. Negative results must be combined with clinical observations, patient history, and epidemiological information."

They also indicate: "The sensitivity is 97.90 %, the specificity is 91.77%."

But when you read the technical document you realize that this was for a subset of patient. The real numbers are 88.7% and 90.6% respectively, and again these are for severe cases.

The two sentence above clearly oversell the product: "refined", "delivers", "help you fly", plus all the details for something that is already known... It's not because everybody is doing glorified marketing, which often results in being deceptive, that we have to be okay with it.

Sorry for the late reply: I don't see how it would prevent infection. It could be useful post-infection, to prevent complications and inflammation. Compared that with the standard of care right now which is simply observing the patient during their recovering.

There are a fair amount of studies who took the initial in vitro results (i.e. cell culture) suggesting non-specific antiviral activity (at that level coca-cola is also an antiviral, antimicrobial, and antitumoral, by the way), into animal or human, and they just did not pan out, because it isn't an antiviral.

I agree in the sense that money will go further when pooled, than if you just give it UBI's style. But, this is a societal crisis, not an individual one. It is not fair to ask people to pull themselves out of a situation that they did not create, but that our unaccountable government did create.

An example: restaurant are struggling and some people need food. Give money to Town gov, so they can buy food from restaurants and serve that in community center. Adjust volume as needed.

Plus the whole financial easing they are trying is dumb. It would be useful if the intention was not to control what is happening with the public markets. We just do not really control those, not on a daily basis anyway. Algorithms heavily relying on market volatility control those, and that is what they are doing right now. So, seeing an administration believing that humans are in control of a mostly automated trading system is dumb.

While the evolution of new virus with pandemic property is not something we control. Its propagation to pandemic level is something we have absolute control on. We are failing as a society, because we allow those things to happen.

It's more like it is the only move we have...

The opposite extreme would be to let everybody get infected, see >15% of the 65+ population die, which I am sure some economic model might favor.

I do hope, but doubt, that this crisis will start changing how our society manages crisis and is pro-active about it, rather than being reactive. I this point I don't care which banner a politician represents. I will only care for the one with a plan for direct accountability at the highest level. Otherwise they're all d-bag.

1st, SARS-CoV2 ELISA already exists. 2nd, the CDC did compare RT-PCR vs ELISA SARS-CoV back in 2005, and ELISA performed really poorly, and that was for acute cases. So, that is why we should stick with RT.

It should help alleviating the symptoms, but is in no way a antiviral.

There's a phase 3 trial for treating pneumonia associated with coronavirus. This is based on prior work showing anti-inflammatory response in rheumatoid arthritis (https://www.ncbi.nlm.nih.gov/pubmed/8278823).

Note that the trial is happening in China (https://clinicaltrials.gov/ct2/show/NCT04261517), where the barriers of entry and approval are quite low.

No.

That would imply 100% infection, at a base reproduction rate of 15 (close to measles), and a mortality rate of 30% (close to Ebola).

If left unchecked covid-19 would infect 100-250 millions Americans. The R0 is 2.5-3. The average mortality rate is said to probably be closer to 1% rather the 3.4% previously advanced, so 1-2.5 millions deaths, which we will hopefully never reach if people follow the current social distancing and self-quarantine guidance.

No.

That would implies 100% infection, at a base reproduction rate 15 (close to measles), and a mortality of 30% (close to Ebola).

If left unchecked covid-19 would infect 100-250 millions Americans. The R0 is 2.5-3. The average mortality rate is said to probably be closer to 1% rather the 3.4% previously advanced, so 1-2.5 millions deaths, which we will hopefully never reach if people follow the current social distancing and self-quarantine guidance.