Alex3917

Homeopathy was invented after the discovery of germ theory [1][2]. So not really.

Germ Theory was only finally accepted (after initially being rejected) due to the advent of evidence-based medicine, which homeopathy popularized.

There is a huge amount of overlap between the genes associated with schizophrenia and the genes associated with autism. This is part of what makes it tricky to diagnose yourself, because anyone who has the genes for schizophrenia is also going to have a lot of autism symptoms even if they don't have autism.

Not to be confused with Google’s existing product called Wiz.

Having worked at both greenfield startups and unicorns, I've found that virtually every problem I've encountered at the unicorn startups was caused by folks being incompetent at the greenfield level. Maybe when you get to the scale of Google things are different, but it's certainly possible to build a business big enough to retire off that doesn't require any more technical knowledge than what you'd learn at a two-person pre-PMF startup.

For both Amazon and Nvidia, their marginal costs are probably much lower than their fixed costs.

Did they buy some code for Gmail from an older company?

They bought both Deja and Neotonic.

I mean the I would really only include the code for things like:

- Fetching email messages

- Parsing email headers

- Mime parsing

- Converting the text of email bodies into UTF-8

- Threading messages

- Eliding reply text

Given that the official story is that pb made the first version of Gmail in a day, does anyone actually believe that he wrote the code for any of those things in a day? If you honestly believe that I have a bridge to sell you.

Wait till you learn that the source code in Chrome also predates the existence of Google.

This is a pretty good talk on the history of email: https://www.youtube.com/watch?v=mrGfahzt-4Q

He wasn't sitting there writing binary code and implementing all 7 layers of the OSI stack by hand, he was was gluing together pre-existing components. And the pre-existing components he had access to include two major email startups acquired by Google in 2001 and 2003, which were founded in 1995 and 1997 respectively. (Although he does have at least two patents for features and algorithms he co-invented while making Gmail.)

You guys cloned a whole suite of products in a short period of time that cost millions of dollars.

At the risk of stating the obvious, the functionality isn't actually cloned, only the UI. The actual code powering Gmail probably dates back to the late 80s or early 90s and has had several hundred thousands of hours of work put into it. This is just a webpage that looks kind of similar.

I point this out only because I've seen people saying that software businesses don't have moats anymore because of this, which is taking away a completely false lesson.

Prompt engineering is like a shittier verson of writing a VBA app inside Excel or Access.

Sure, if you could use VBA to read a patient's current complaint, vitals, and medical history, look up all the relevant research on Google Scholar, and then output a recommended course of treatment.

This is the key issue. There is zero doubt whatsoever that flossing is essential, and the fact that the empirical evidence is equivocal shows the limitations of science to prove even the most obvious things.

What’s stopping a similar crisis that 23andMe customers faced where their genetic data along with their identifying information getting sold to the highest bidder if you ever become insolvent?

Nucleus employee here. Nucleus is a medical provider that is providing a medical service and is regulated by medical laws, which extend even through bankruptcy or acquisition. Whereas 23andMe was essentially an entertainment company and was regulated as such, which is what enabled that unfortunate situation to occur.

But then at the end it added a "Fun fact" that unicode actually does have a seahorse emoji, and proceeded to melt down in the usual way.

To be fair, most developers I’ve worked with will have a meltdown if I try to start a conversation about Unicode.

E.g. if during a job interview the interviewer asks you to check if a string is a palindrome, try explaining why that isn’t technically possible in Python (at least during an interview) without using a third-party library.

There is at least one service that scrapes and archives the DKIM keys of popular websites.

More common than needing stitches? That’s hard to believe.

It’s still the best measure we have, though you should obviously know that LDL measured while on statins is lower than it would be normally.

I'm not a doctor, but doesn't LDL basically just prevent the body from healing damage to the epithelium, which comes from things like high blood pressure and inflammation? Unless my understanding is wildly off base, it doesn't really make sense that a thing that merely slows down the healing process would be more predictive than the things causing the damage in the first place, given that if you aren't accumulating significant damage then your levels of cholesterol are somewhat moot.

Seems like a reasonable policy. Given that the most talented tech workers, the ones the H1-B visas are designed to make it easier bring to the U.S., are getting $100M+ signing bonuses right now, a $100k/yr fee seems pretty trivial in comparison.

Given that AI has made repeatedly pulling the lever on the world's biggest digital slot machine feel like building a valuable software business, is it really any wonder that a lot of the younger founders who are raising seed rounds are really just glorified tweakers? I was recently on the market for a new job, and within two months I talked with three different founders who, pre-AI, may well have been "employed" stripping bicycles for parts to sell for meth. But now, thanks to Claude and ChatGPT, these folks are now able to vibe up enough traction to raise a couple million bucks in a seed round.

The fact that most of these folks are going to fail doesn't especially bother me. After all, that was true for previous generations as well. What's different now is that a lot of these folks not only won't be coming away from these experiences having developed marketable skills, but many of them will have significant health problems that prevent them from doing so in the future.

I'm actually very bullish on the use of AI in software development overall. But when placed in the hands of folks who haven't yet had the time to develop hard skills, it both enables and incentivizes cutting corners to an alarming extent.

Next.js is easily the worst technology I've ever used.

To be fair, this is partly on the kind of people who use it. E.g. if you're trying to build something that's intended to last for 10+ years but you don't think it's worth it to spend the 20 hours watching the Udemy course on Angular, then your technology is going to be a complete dumpster fire no matter which stack you choose.

Really just one major breaking refactor in 13 years, and that is partly because not only have we learned a ton, but browsers themselves have changed dramatically. I'm not going to say it was perfectly handled, but they also didn't have nearly as much support from Google back then.

I find it a tough sell to add another 20 years to life expectancy

20 years would be difficult, but 10 or so years would be very attainable.

em dashes are for denoting emphasis, whereas en dashes are for connecting compound words or phrases.

I'm more talking about the particular contrastive structure.

But that's one of the main uses of emdashes, for signaling that the second half of the sentence is more important than the first half. If you Ctrl-F for emdashes on my blog, you can see I do it everywhere, even though all of my posts were written before LLMs existed:

https://alexkrupp.typepad.com/

I can't stop seeing the LLM verbiage everywhere I look.

emdashes have been pretty popular among net native folks for the last 20+ years, e.g. if you were to look back at the most popular Kuro5hin stories from ~2001 - 2005, you'd see them everywhere. People just aren't used to the average person being able to write well, so it looks weird to them.

I mean with LLMs you just copy-paste in the input format of your new CMS and then upload your export file. Even if it only took 15 minutes before, it now takes 0 minutes.

At least with LLMs, we can just write a query to migrate the export to whatever target format we want. The main issue is just breaking 20 years worth of inbound links.

I have no doubt that it wasn't vc profitable, but my assumption (without any inside info) is that the real issue is that they were using some hacked up version of Movable Type that they couldn't upgrade.

It's frustrating though because imho it's arguably still the best blog platform to this day.

This. Claims of a universal antiviral are as old as western medicine itself. Literally the only reason anyone knows what the Hippocratic oath is is because Hippocrates was already famous at the time for promoting elderberry as the universal antiviral.

From that perspective a one person unicorn is very feasible if we think about it as building a network effect monopoly.

To build a one person unicorn, the main thing you need is an arbitrage opportunity for getting users that is unattractive to multi-person companies. Once established, this business may well turn into a network effect monopoly, but I don't think that is the crux of what is needed to get going.