HN user
It's certainly quite pleasant to work with...but I would rather use sql for etl, the backend be whatever it needs to be...
The real world data transformations can get gnarly very quickly and sql is the perfect common debiminator compared to dplyr which is still niche...
How do you feel about polars?
Well the onus is obviously on a driver to make sure they see what they need to see. And that they drive a vehicle that allows them to see things.
That doesn't mean the pedestrians should not be careful...
I looked it up and it's quite fascinating indeed but I cannot stop thinking about sanitary challenges...
I am not sure what specifically you mean by "AI" here but it's a bit naive (no offence) to think the field is so dumb that it haven't been looking at "AI" for a few years already. See https://www.biorxiv.org/content/10.1101/2023.10.02.560464v1 for instance
nostos/limbus, genoox, engenome, congenica are a few companies/products that I have heard about and have been around for years (the last one was defunct from what I heard last however).
Disclaimer: not affiliated to any of these.
Thanks for the reply. I have read your post but I haven't seen the preprint obviously and without knowing the details I remain skeptical.
The WGS NICU diagnostic rate is only ~30%, depending on who you ask.
Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense.
I'm planning on publishing evals and benchmarks in the next few weeks, but out-of-the-box systems actually don't do very well for a variety of reasons.
Happy to see it. I wish you all the luck and will be the first one praising your solution if I see convincing results.
The post is written almost as if there is no prior art on (germline) variant interpretation. In fact, it is an established niche field with multiple commercial vendors existing for years (and diagnostics for critically ill infants is the most well known use case - google Stephen Kingsmore or Rady's children hospital for one). I'd be surprised if the approach is really something novel at this point.
It is definitely the case that the parents of babies and kids with life-threatening conditions are often one the most motivated people you see on Earth and what they accomplish sometimes is truly incredible. My heart goes out to them including the OP - I can only imagine how hard it must be....
These are not bankers, but the culture is still bonkers
You are asking about one-sided vs two-sided tests. Not really "more often" because formal type 1 error rate is still the same. I'd say two-sided tests leave more space for post-hoc theorizing but there are valid situations when there is no clear one-sided hypothesis a priori. Do we really know whether that the hypothesis should have been "ruder prompts are better"?
I'd say this is benign compared to other ways of (mis)using statistics e.g. looking which way the difference goes and then running one-sided tests or tweaking the setup until one gets "significant" p vals.
EDIT: I looked in the paper again and noticed that they actually did pairwise t-test on all possible combinations of tones. They should have adjusted for multiple testing since they are doing 10 tests (choose 2 from 10) and not one.
Interesting.
I am wondering why would anyone use a t-test when the experiment is clearly modelled by a binomial distribution: 250 independent questions and each one is either answered correctly or not (the null is that the success rate is the same).
10k only??? Incomparable to the value delivered any way you measure it...
It's suddenly you who's deciding for others what's stupid?
Exponential productivity gains?;)
Customers dictate what gets produced.
Sure? It seems to me that the companies dictate what I consume. Many many times I wanted to buy exactly the same clothes item or shoes to replace an old one (because I know exactly how it'd fit and wear) only to discover it has been discontinued with no obvious "heir". Sometimes only 6 months later...
Whats the percentage of people chasing "fashion", especially after mid 30s?
Why massive discounts seem to be much more of a thing in the US compared to Europe?
ra is autoimmune
If anything focus gets better without sugar and excessive carbs for me - but those work well for outdoors or workouty days I find.
Looks like it's true that low-carb adapted athletes rely more on fat oxidation during exercise but performance suffers nonetheless because of increased oxygen demands that basically cannot be met.
If your employer gets you a nvda card or openai subscription, it doesn't automatically mean you are getting richer, agreed?
And the richness of life it's another philosophical discussion altogether...
Yoir choice between the red pill, the blue pill or no pill is pretty obvious but this choice is highly subjective.
Also pfizergate featuring von der leyen.
I'm with you on this. People who pathologize themselves or others - assuming they're malfunctioning rather than acknowledging they might simply be living a life that doesn't fit - have a very limited way of looking at things.
... in professions where skill is essential and performance is both visible and attributable to a specific person, particularly in fields such ... fund asset management ...
Laughing out loud)))
How is it unstable? It's one of the most reliable pieces of software I have used honestly.
In any case 'nix-shell -p erlang|elixir' does not seem too complicated to me.
Well Nix is the only sane way I know to manage fully reproducible envs that incorporate programs/scripts spanning multiple ecosystems. Very common situation in applied data analysis.
Yeah I think there's no point denying that we humans need and are affected by narratives. At least on the psychological level, which, in turn, may have impact on the body as well.
Moreover, the republicans are reported as having lower T on average but the difference is not statistically significant.
It looks weird to me they don't report how age behaves across groups and don't correct for age in baseline comparisons.
What's quintessential quant finance? Black-Scholes and no-arbitrage pricing. Don't you agree it's much more of a tool than a theory of how the world works.
Excuse me? Quant finance doesn't claim to be devising grand theories about how the world operates (is more akin to engineering). And when it does, any delineation from economics is moot.
Modelling isn't the higher intellectual pursuit it's made out to be. Imo designing theoretical models post-hoc to "support" a desired conclusion is not unheard of in econ/finance.
Imo the economics profession very much suffers from inferiority complex known as "physics envy".