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0xWTF

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old.reddit.com 13d ago

When does a CEO get involved? When you're on your fourth Ford Focus

0xWTF
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interconnect.substack.com 3mo ago

Chinese Open Source – A (definitive?) history so far

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www.cape.co 4mo ago

Cell Service for the Fairly Paranoid

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news.ycombinator.com 5mo ago

CFO says "Everyone uses Excel, definitely not Sheets. Get over it". True?

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www.dsp.dla.mil 5mo ago

DoD Supports Modular Open Systems Approach (MOSA)

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news.ycombinator.com 6mo ago

My daughter's boyfriend gave me a custom keyboard? I don't like it. What now?

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www.youtube.com 6mo ago

From Starbase: Pete Hegseth on Defense Innovation Reform [video]

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www.nejm.org 7mo ago

Venture Capital Investments by U.S. Academic Medical Centers

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www.nytimes.com 8mo ago

Wirecutter buys 450 lb box of Amazon returns

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www.reddit.com 8mo ago

Redditor digs up 1961 oceanographic survey data to answer random question

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www.youtube.com 9mo ago

Drew Cukor – AI Adoption as a National Security Priority [video]

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1pts0
pmc.ncbi.nlm.nih.gov 10mo ago

Mortuary rites of the South Fore and kuru

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3pts0
brave1.gov.ua 11mo ago

Brave 1: Key development needs for Ukraine to win the war

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johnlind.tripod.com 1y ago

John Lind's The Science of Photography – a great piece of the "old web"

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news.ycombinator.com 1y ago

Do countries with denser social graphs have better outcomes?

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whistlebloweraid.org 1y ago

Whistleblower statement on anomalies at time of DOGE work at NLRB [pdf]

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www.fiercebiotech.com 2y ago

Ginkgo Bioworks 'A Hoax for the Ages,' (2021)

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news.ycombinator.com 2y ago

Ask HN: What's Your NAICS Code?

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www.diu.mil 2y ago

Come help build a new digital front door for Defense Health

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www.diu.mil 2y ago

RFP – Help Defense Health Agency build their digital front door

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www.ai.mil 5y ago

JAIC, in Partnership with DIU, Delivering AI-Enabled Cancer Diagnostics

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1pts0
github.com 6y ago

Coronavirus Diary: Ethically sourcing data for the fight against disease

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4pts1

I haven't finished reading, but I should note for the group that the author doesn't represent the Anthropic situation accurately. Emil Michael, the undersecretary of war/defense for research and engineering went on the All-In podcast (1) and explained, for quite some time, exactly what happened. You should go listen to it (2). In essence, in the negotiations, Dario kept coming back saying "well, if you need it, call us, we can redline things as needed". This happened over and over and over. Emil's point was that a major conflict, if it were to occur, might happen on the 30 minute clock of an ICBM, and all due respect to Dario, the national security apparatus just doesn't have an allowance in that 30 minutes to call him for a redline. Emil felt Dario had demonstrated he wanted ultimate control via line item veto, and was willing to trade up to and including the survival of the nation for that veto. And a government cannot be expected to pay for that sort of behavior from an entity domiciled in their jurisdiction.

Now, Dario is going to win a decent slice of the economic pie. But as an military acquisitions matter, I gotta say, I have to agree with the undersecretary's position here, and yeah, it makes sense to document a company's undesirable behavior, and in certain circumstances push that information to others. Not the first time the government has found a company under contract acting in a way that appears to be counterproductive to the government's obligations; there's a whole database full of this stuff (3).

1) Without a doubt, All In is a friendly crowd for Emil, but I think that actually made it easier for him to get more nuanced facts out in this case because he wasn't spending a lot of time defending malignant attacks.

2) This link should jump to the relevant segment https://www.youtube.com/watch?v=gzwRflcLPAA&t=2479

3) http://www.ppirs.gov/

Patient: "I want high quality care with good follow up."

Doctor jots down key bits on a paper chart.

Patient: "I want my records to go with me."

Doctor takes notes on computer.

Patient: "I want to sue my doctor if things go wrong."

Doctor takes copious notes on computer.

Patient: "I hate my doctor looking at the screen instead of me."

Doctor gets an AI scribe.

Patient: "I want my doctor to take the notes."

Doctor: sigh

The weird edge cases that live around connectors never cease to amaze. I recall one, I think it was also HDMI (maybe displayport or VGA), that showed there's a very low resolution digital graphic or text signal and some connectors even have a screen embedded in them.

Ok, so what has happened historically when we hold a tech stack constant for 10 years? Versioning proceeds, but everyone consolidates on a thing?

Python? => Data science. Sure, python is just importing the C tools that do the heavy lifting, but look me in the eye and tell me R, S, SAS, or SPSS won.

C? => I mean, everything? But what happened in the first 10 years? Proliferation of operating systems and linear algebra libraries?

So, generally, the grey beard talent consolidates their intellectual contributions and uplift everyone else. Is that true? -ish? Missing the mark?

Guys, I'm a knuckle-dragger, I genuinely don't know what I'm asking. What are the tech stacks that were held constant (by whatever factors) for a decade, and what came out of it?

Is this the decade where art directors takes over gaming?

Interestingly, Id was led by John Carmack, who was also a big fan of VR. And Microsoft killed the AR/VR/MR teams a year ago.

So, I'm guessing internally there were some leadership hopes that IdTech would help support IVAS and related professional AR systems and when those failed to be adopted at scale, IdTech lost a key sponsor. I'm guessing it's been a rough year of internal advocacy since.

I can see where Goodhart's Law applies to psychology and economics, pretty much any man-made domain without IDLH (immediate-danger-to-life-and-health) outcomes. But I think it's going to be hard to Goodhart a lot of medical AI safety. Biology doesn't give a shit.

However, identifying the right metrics and having the necessary test sets will, at times, be challenging.

Women want their own income stream because of the innumerable ways men get into trouble. If her man gets into trouble, she wants a plan B, for her and her children. I don't think anyone was thinking about how that would prop up the housing market 30 years later.

I have already forwarded this to a number of senior pathologists and industry leaders. People who are in charge of either developing these things or validating them for clinical use. We'll see what they say. But I suspect a great many of them will actually continue using the implicated products because they passed clinical validation at many institutions. TBD.

I think the regime is very weak.

The "enemy of my enemy" concept suggests that even if the people hate their government, their immediate pain is being caused by the United States and Israel, so I'm less confident about that.

Iran does not think they are dealing with a madman.

Iran does think they are dealing with a mad man, or at least a government practicing a policy (as the US administration's apologists have termed it) "intentional volatility".

A far more interesting issue here is the oil supplies available in the Pacific. Brunei, Malaysia, Vietnam, Indonesia, Australia, and others are all ramping up production capacity. Non-OPEC oil production is increasing generally in response. This is likely to undermine the Middle East's ability recovery from current constraints as non-OPEC players gain clout in the markets.

Right now people are talking about China and California have limited supplies. But those are enormous, powerful entities that are deploying multi-pronged strategies to secure energy resources. Look at what they're doing and bet there. You also see developing countries retooling to support less oil-intensive economies, like increasing work-from-home options. Solar and wind are currently feeling weak without their subsidies but are exhibiting staying power as people look to move off more petroleum-dependent energy resources.

As for the tactical issue, the concept people seem to be trying to get at is "cost-per-kill". That needs to come down. Yes, we can kill drones with supersonic interceptors. But spending $6M to shoot down a $6K drone has terrible long-term economics.

Googlebook 2 months ago

I love the mix of MacBook Pro and Asus-style renders. Nothing says care and attention to detail like mixing renders in the same advert.

It was not only the FDA that stopped snake oil. A lot of it was also stopped by state licensure and medical school accreditation (see the Flexner Report), all of which happened in roughly the same era.

What I take from this is that AI code, biology, etc, will not announce itself. We will have to announce the human-produced content. Introductions are about to be ritualistic again. Queue humorous (but not really all that valid) counterpoint: https://www.youtube.com/watch?v=hoe24aSvLtw

... in male mice.

I think savvy universities want PIs who are savvy enough to realize that the point of these is to boost measurable visibility like citation count and h-index, so the headline of a news release boosting the article doesn't matter. They can always blame a copy editor for the headlines. It could read "world peace solved with moon juice." The provost would only care if it generated negative feedback. So it's the PR department's job to juice it as much as possible without getting blowback.

So, to make this concrete, Akasa uses computer vision to read medical records to replace medical coders because there aren't enough medical coders to get all the billing right and medical systems leave like $1T a year on the table.

The EHRs could give companies like Akasa API access so Akasa could then just run NLP, but the EHR vendors don't grant various third parties API access for various reasons, so instead Akasa gets a seat license for each medical system they service and uses computer vision to read the screen (a cadre of Akasa medical coders review errors to stay up to date with unannounced changes from the EHR vendors) and then runs the NLP to figure out which CPT codes to assign to actually put in a bill and send the payer so the hospitals can stay afloat.

So this 45x delta is how much more the medical systems pay Akasa because Epic won't work with Akasa.

This is but one example of why US medical bills are outrageously high.

I came back as with a measure of 174 and a label of "true neutral".

However, I know enough about perception to know that this called for some hacking.

So as soon as I saw the second color I realized I needed to look at something else. So each time after choosing and seeing the next color I looked around quite a bit, inside and through the windows at the outside (I happen to be in a Hawaii, so blues and greens are abundant) before choosing and I noticed significantly different color perception after looking around, specifically, I had more confidence in whether it was blue or green.

I can imagine if you just stare at the colors and try to power through, you might get kinda irritated.

Operation Paperclip

Even without internet, many of the scientists of Eastern European extraction were able to share secrets to the Soviets. I don't believe any Operation Paperclip scientists were directly implicated as atomic spies (and there may be some reasons the US wouldn't want to bring attention to that), but plenty of other operations occurred, and plenty of other scientists did in fact share secrets with the Soviets.

Now, with the Internet and strong crypto, it's trivial for Chinese professors to send IP back to collaborators in China. That is the basis of the 1000 Talents Plan (1), one of 200 Chinese "talent recruitment" plans.

This is not at all hypothetical. I used to swim with Kang Zhang, who has done amazing work to cure chlamydial blindness, but also took that IP from the US to China (2). Another ophthalmologist would drive all the way from UCLA (the north end of LA) to San Diego to swim with us. I asked him why. He said it was to keep an eye on Kang: he had more macaques in China to run experiments on than anyone in the US could possibly access.

(1) https://en.wikipedia.org/wiki/Thousand_Talents_Plan

(2) https://en.wikipedia.org/wiki/Kang_Zhang

What's even more important is how solar, and to a lesser extent other tech, served as a gateway for China to accumulate electrical engineering, physics, and chemistry talent the US seems committed to offshoring by incentivizing universities to hire the cheapest available grad student talent (inevitably from China). We are training them and not our own.

There are two teenagers who learned about Malus in the last hour and have started figuring out how to actually build it, right now. They will not cite their source in their IPO statements.

3M-052 again? Oh, for fuck's sake. We've been down this road for 15 years now. Every funder who learns about the interferon cascade gets a boner. And then they go to animal trials and meet disappointment. If these guys can get to an IND, good on them, but 3M is really licensing the shit out of this one.

Meanwhile, if you've got spare millions laying around, have a look at ENA Respiratory. They've already done a Phase 1 in Australia (entirely admissable for the FDA). Turns out hypoxia creates and anxiety and old people have most of the world's wealth, so COPD is a lucrative market.

Another super interesting one is Lumen Biosciences - can't make oil from algae at a viable price point, but for sure they can hit pharma price points, even food supplement price points.