Deletion of Il11 extended the lives of mice by 25%

https://www.nature.com/articles/s41586-024-07701-9

by Nazzareno • 2 years ago

48 9 2 years ago

nature.com

Supermancho• 2 years ago

I immediately wonder how this affected the EOL conditions of those mice.

rexreed• 2 years ago

They outlived their retirement savings and had to re-enter the workforce. It's just a rat race, isn't it.

hi_hello• 2 years ago

Not to mention the radical cost of living adjustment, renting some hole in the wall just to squeak by.

beowulfey• 2 years ago

Article states they had fewer biomarkers of aging, and showed less age-associated obesity, fraility, and metabolic decline. So their "youth" period extended longer.

Actually the point of healthspan vs lifespan is made in the introduction -- it was a justification for using mice for this study, which have clear health phenotypes that are analogous to humans.

PaulHoule• 2 years ago

I'm basically skeptical of any longevity study in mice or yeast or C. Elegans because I think humans already have superior longevity factors over other animals because of our culture: we can live 3x reproductive age and still contribute to the survival of our descendants and our tribe.

Metabolic adaptations that prolong the life of mice might be just bringing them closer to where we are as opposed to something that would work for us.

gumby• 2 years ago

It switched them from CRLF to \n?

xk_id• 2 years ago

The only significant, deleterious phenotype in il-11 KO mice is the inability to sustain pregnancy. So far it seems to have a very high safety profile.

ChrisArchitect• 2 years ago

[dupe]

Discussion: https://news.ycombinator.com/item?id=40987224

Deletion of Il11 extended the lives of mice by 25%

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