First-in-class MKK4 inhibitors enhance liver regeneration, prevent liver failure

https://www.cell.com/cell/fulltext/S0092-8674(24)00225-3

by birriel • 2 years ago

111 14 2 years ago

cell.com

axus• 2 years ago

I appreciated seeing an article on the other end of the spectrum from the dark matter skepticism on sciencealert.com

yesbut• 2 years ago

Soon restaurants and bars will hand these out free, along with statins, with every cake, pie, and alcoholic beverage.

astrange2• 2 years ago

Statins have dangerous downsides; they give some people uncontrollable anger.

Smar• 2 years ago

This souns a lot like ethanol.

sva_• 2 years ago

It makes some people very mellow as well.

valec• 2 years ago

more concerning are the effects on muscle tissue

giantg22• 2 years ago

Technically they could be doing that with NAC already. But as long as people aren't binge drinking, it's not really a problem.

nkozyra2• 2 years ago

I'm pretty sure NAC is sold at a lot of bars but it's not a liver cell regenerative.

ethbr1• 2 years ago

As a non-biologist, interesting on the molecular work to get from vemurafenib to HRX215. Modern biochemistry for drug discovery is fascinating!

Also, small sample size, but the 85% hepatectomy in pig model results are interesting, where liver efficacy seems to be boosted enough to prevent systemic collapse post-surgery, at a normally lethal removal amount?

That's a pretty smart experiment for "Does this drug do what we think it does, or are we misreading other results?"

Pokerface777• 2 years ago

Is this already available?

OJFord• 2 years ago

Fourth bullet point right at the top is that they've just completed a phase 1 trial. So, outside of the trial, no.

First-in-class MKK4 inhibitors enhance liver regeneration, prevent liver failure

Related Stories