Breakthrough Drug Achieves 65% Reduction in Genetic ‘Bad Cholesterol’

https://scienceswitch.com/2023/08/30/breakthrough-drug-achieves-65-reduction-in-genetic-bad-cholesterol/

by conse_lad • 3 years ago

14 3 3 years ago

quinncom• 3 years ago

Here’s the RCT paper: “Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation” by Stephen J. Nicholls, MBBS, PhD; Steven E. Nissen, MD; Cynthia Fleming, RN, MSN; et al.

https://jamanetwork.com/journals/jama/fullarticle/2808864?gu...

“Oral doses of 30 mg to 800 mg for 14 days resulted in increasing muvalaplin plasma concentrations and half-life ranging from 70 to 414 hours. Muvalaplin lowered Lp(a) plasma levels within 24 hours after the first dose, with further Lp(a) reduction on repeated dosing. Maximum placebo-adjusted Lp(a) reduction was 63% to 65%, resulting in Lp(a) plasma levels less than 50 mg/dL in 93% of participants, with similar effects at daily doses of 100 mg or more.”

JoeAltmaier• 3 years ago

Now, to see if lowered Lp(a) plasma levels relate to better health under this treatment.

kridsdale3• 3 years ago

That will likely take a decade or more to bear out.

Breakthrough Drug Achieves 65% Reduction in Genetic ‘Bad Cholesterol’

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