Impact of xenoestrogens on male fertility: a systematic review (2019)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601394/

80 13 6 years ago

ncbi.nlm.nih.gov

I have a hard time parsing the outcomes section, the last sentence seems to contradict the previous ones?

„ A total of 25 experimental studies and 44 epidemiological studies were included. Consistent effects of analgesic and phthalate exposure on human fetal germ cell development are demonstrated in experimental models, correlating with evidence from epidemiological studies and animal models. Furthermore, analgesic-induced reduction in fetal testosterone production, which predisposes to the development of male reproductive disorders, has been reported in studies involving human tissues, which also supports data from animal and epidemiological studies.“

And then:

„ However, whilst reduced testosterone production has been demonstrated in animal studies following exposure(s) to a variety of environmental chemicals including phthalates and bisphenol A, these effects are not reproduced in experimental approaches using human fetal testis tissues.“

e2e8• 6 years ago

Last sentence is about environmental chemicals. Previous sentence is about analgesics.

MrBuddyCasino3• 6 years ago

So its analgesics vs „environmental chemicals including phthalates and bisphenol A“? Plausible, though they really should have worded that differently.

My takeaway: keep painkillers like Aspirin, Ibuprofen and Paracetamol away from fetuses and small children.

DoingIsLearning• 6 years ago

So is the conclusion that bisphenol A and phthalates disturb testicle development in fetus, but that we should still try to study this in bigger datasets?

To be practical then, pregnant women should avoid plastic containers with bisphenol A and phthalates?

I always find most systematic reviews very defensive about drawing conclusions, I understand this is due to the fact that the evidence is often from dissimilar data or experiments, but often it just hides clarity.

cies3• 6 years ago

BPA is everywhere. For example, I learned receipt paper (that stuff that comes on rolls) are coated with it. It needs to be classified as toxic, but industry does not have an alternative, so it gets pushed fwd again and again.

est31• 6 years ago

In theory, BPA on receipts is banned in the EU since January: https://echa.europa.eu/en/-/bisphenol-s-has-replaced-bisphen...

But many places still give BPA based receipts, and many have switched to BPS instead.

bencollier49• 6 years ago

Paracetamol?! That's astonishing. I appreciate that this is about in-utero expsoure in the first trimester, but I can't help pondering the widespread overuse of Calpol in children (or whatever you call it in the US).

Impact of xenoestrogens on male fertility: a systematic review (2019)

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