HN user
NMDA receptors, and their modulators like Sarcosine and Glycine, have been a topic of interest of mine, specifically regarding schizophrenia.
I have a blog post compiling all my research here:
This makes good sense in my experience. I was struggling socially and academically in college so they proctored an IQ test to look for things like ADHD etc. I scored in the 98th percentile for verbal comprehension. Only 2 years later did I have my first psychosis and was diagnosed with Schizoaffective. Luckily after a few rough years I'm doing well on the lowest dose of an antipsychotic and can function in society again. But there are definitely cases of highly creative or people with strong language skills that the expression goes too far like this post suggests.
Naltrexone will do the same thing. For alcohol, opioid, or binge eating control. Improve T3 and helps with blood sugar, and its orally bioavailable.
Here's a few studies on both for reference:
Sarcosine:
https://pubchem.ncbi.nlm.nih.gov/compound/Sarcosine
The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518924/
Efficacy and cognitive effect of sarcosine (N-methylglycine) in patients with schizophrenia: A systematic review and meta-analysis of double-blind randomised controlled trials https://pubmed.ncbi.nlm.nih.gov/32122256/
Two grams of sarcosine in schizophrenia - is it too much? A potential role of glutamate-serotonin interaction https://pubmed.ncbi.nlm.nih.gov/24523591/
BPC-157:
Pentadecapeptide BPC 157 and the central nervous system https://journals.lww.com/nrronline/Fulltext/2022/03000/Penta...
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/
A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine https://pubmed.ncbi.nlm.nih.gov/9547930/
BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling "Negative-Like" Symptoms of Schizophrenia https://pubmed.ncbi.nlm.nih.gov/35884767/
Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats https://pubmed.ncbi.nlm.nih.gov/15840402/
Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances https://pubmed.ncbi.nlm.nih.gov/11978191/
It sounds like you’re getting all the nutrients needed to create gastric juices.
Here’s a link to a study: https://journals.lww.com/nrronline/Fulltext/2022/03000/Penta...
As someone with Schizoaffective this works for me. Going to start eating more veggies!
Thank you for being open and sharing your experience. I appreciate you sharing your dietary expertise. I’m currently in the middle of Dr. Hyman’s UltraMind solution book and plan to add your suggestions to my diet. Personally I’m diagnosed with Schizoaffective disorder, and thought to add my experience as well. I ate junk for over 20 years growing up which didn’t help my brain/gut.
In addition to foods, two things that have helped me tremendously and have not given me the horrendous side effects of Antipsychotics are what I’m currently taking:
- Sarcosine 1 gram/day (dissolved in water) -- An amino acid that occurs naturally in foods such as egg yolks, turkey, and legumes, and can be bought as a dietary supplement.
- BPC-157 250mcg ever other day (enteric coating capsule) -- Which is composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice
(Don’t blindly take my advice or change medicines without supervision, I make no guarantees on efficacy or safety.)
I have a good deal of research notes on what I’ve found on why they work but hacker news has smarter people than I and would love to hear from others. The brain gut connection is massively important.