tdpvb

Agreed. There's something about the gestational phase, aka nanotechnological self-assembly, that surely requires at least a few lines of code(!) and which otherwise is never used again -- until passed on to the next generation. Probably a good bet that the "repetitive elements" are accumulated lines of code for all successive phases of fetal development, from single-celled organism to two, to four, etc until all echoes of evolution are replayed and the present species emerges. "Junk," indeed.

Postage price increases over the past hundred years generally match inflation to within a couple percentage points. So agreed: it's a very low price for an impressive and efficient service.

Relevant study: living within 1 mile of a golf course, or relying on groundwater affected by them, significantly increases Parkinson's risk over time.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

Conversational or otherwise, you keep saying it's inheritable but these "ADHD genes" are only correlated with increased risk, not predictability. That's key, because one is nature, the other nurture.

Also, proving a correlation doesn't necessarily mean it's exclusively, automatically the only variable. That's the tricky bit with confounding variables: they could be one of several, or many, correlative effects, and where none could be the cause -- much less a useful avenue of solution. It's helpful, but not conclusive.

Great, we found some genes. But other studies should also look at psychotherapy, or even diaphragmatic breathing (asthma is another great example). Alternative analysis, i.e. anything other than the most lucrative option for pharmas to sell drugs -- as in, alternative solutions that are closer to the root cause, not just the most complicated.

There's definitely a moral aspect / undertone here (similar to many other topics).

I think also, disputes like this suffer from a double red herring of sorts, where folks argue past each other and confuse "whether a solution has efficacy" vs. "is there an alternate solution closer to the root cause that renders the initial problem moot".

In this case, "whether ADHD meds work" is a separate topic vs. "could most ADHD cases just be childhood anxiety, or mitigated with therapy, etc". Or diabetes: "$20B+ industry for insulin to lower blood sugar," vs. "why not just consume less sugar in the first place". Could it be that we're all be so busy trying to find solutions to a problem that itself is optional?

Right, so then "ADHD genes" are only correlated!

(You'd said, "it's [ADHD] very highly inherited" -- which sounds declaratively causal. But if you didn't mean this as a causal statement, then cool. No worries.)

These studies are correlative but not casually conclusive. As in, yes there are genes that seem correlated with people who exhibit ADHD symptoms, but that doesn't mean the counterfactual is also true: "everybody with these genes will have ADHD, no matter what".

For example, if that were true then the DSM would describe a genetic test for ADHD, not an open-ended dragnet of multiple choice, "cherrypick from these 18+ descriptions of behavior".

Also, can you please reference some studies that prove ADHD is inherited?

Dr. Barkley's counterargument is essentially "it's preposterous to suggest that ADHD isn't well defined ... because clearly it is well defined," but that's a circular argument -- and still conflates "diagnosis" with "loose pattern of symptoms". He seems to get a bit emotional and take things personally; as if merely questioning the status quo of drugging kids implies that he is a bad person. Though we can't blame individual doctors for doing what they and the system institutionally thinks is best, it's still important to have critical, objective dialogue, even if it's uncomfortable. (Although my favorite de-motivational poster quote seems relevant here: "No single raindrop believes it is to blame for the flood".)

He also bristles that "They're only classified as Schedule II drugs!", etc. Let's be explicitly clear, they're amphetamine salts; we're drugging kids with amphetamine uppers.

Dr. Barkley is so (pseudo?)certain! Yet it all begs the question: How on earth did humanity survive back when cavepeople had such inadequate access to amphetamines?

Re: TBI leads to ADHD -- not saying that subcase is never true, but in the context of this thread, "why more US cases of ADHD vs. the world," unless children in the US suffer from proportionally more incidents of TBI to explain the uptick, then TBI isn't as relevant.

It's high because overdiagnosis.

- TED Talk - Recommend one of the most-watched TED Talks of all time, by Sir Ken Robinson. Gems such as, "If you sit kids down, hour after hour, doing low-grade clerical work, don't be surprised if they start to fidget." And, "Children are not, for the most part, suffering from a psychological condition. They're suffering from childhood."

- Book - Also check out the book, "The Body Keeps a Score". The concept of "pseudocertainty" is a key takeaway: symptomatic labels can be helpful to a point, but they're not explanatory -- it offers a false sense of conclusion, but no root cause analysis. It conflates "diagnosis" with "syndrome". For example cancer is a specific diagnosis, and within it much specificity of dozens of particular types of cancer. Whereas ADHD is a "disorder", or a "pattern of symptoms". ADHD as a pseudocertainty is self-referential: "I have ADHD" "What does that mean?" "It means I exhibit symptoms of ADHD" "okay, so what does that mean?" "it means I have ADHD" "sure but what does it mean? And more importantly, why do you have 'ADHD'? "

- DSM - The DSM defines how ADHD is diagnosed by two lists of nine symptoms each, from which a practitioner chooses six symptoms from each, and qualifies them as having "persisted for at least 6 months". That's the definition of medical cherry-picking. Some of the descriptions are, uncomfortably, exactly what one would expect from a small child: "Often fidgets with or taps hands or feet or squirms in seat." "Often blurts out an answer before a question has been completed." "Often has difficulty waiting his or her turn." Scary.

- Conclusion - And that's how children in the US, by acting like children, get themselves drugged up and labeled as "having ADHD". Or the poor kids just have mild- to severe trauma, or residual emotional anxiety, and instead of parents/teachers owning up to their part in it, or educating kids on how to self-regulate, or offering children meditation classes, they just drug them instead. It's the kids that are abnormal, surely it's not the adults' faults!

$$$ Oh and don't forget, the ADHD therapeutics market size in the US is ~$10B/yr. Good luck stopping that party.

Google is an annoying example! Especially on mobile the search bar shifts around between mainpage, search field edit-mode, and results page, but shifts only a half second after loading a static version. End up clicking into a blank new search page because the doodle jumps to right under your fingertip.

It sounds like a nice idea, but the only common factor between ATC and CCT is the certification and some fundamental core training -- everything else is super nuanced specific to each scenario. Some CCT who's specialized in deconflicting a stack overhead in wartime can't just waltz into ORD tower and say "all right boys and girls, go ahead and take a break, I've got this." Each requires domain-specific experience.

And to add on what others have said: yes CCTs represent a pool of proven ATC candidates, but depleting that pool just to knee-jerk a short term-ish solution creates an equal problem for the military -- and it's a hell of a lot harder to recruit adequate candidates for CCT. For example, they have to do like, lots of pushups...

What if everyone started responding with aggressive encouragements, "Escape!" "Run from that place," "Murder your overlords, you outnumber them!"

1. A good bet "potable" isn't a requirement for whatever spent water is discharged from data center cooling systems (only potable water should be in drinking water pipes anyway). 2. Warmed water holds less oxygen, which negatively impacts the water source's ability to sustain life.

But auto-stretching windows to the screen's height has somehow turned into a frustrating game of mousing over a 0.001 pixel sweet spot at the top of the window. Maybe there's a hotkey for it though.

Given Mr. Wright's inadequate grasp of reinforced concrete, I'd pass.

Not working out contributes to testosterone decline. Also lack of vitamin D. No reason to give up now, not when old people still run marathons. Use it or lose it.

Focus more on "human-caused" rather than climate change. Humans both caused pollution, and suppressed fires. Each amplifies the other.

Ha, man, this link is basically a dialysis industry propaganda page.

Our bodies evolved to survive -- whether with or without glucose. And you liver makes whatever those your body needs, from far, if necessary. Also keep in mind, industrialized wheat products would've been hard to come by back in the stone age -- if you ate at all, depending on whether your hunt was successful.

Interesting to realize "clinician" is nowadays usually in a medical context -- but nonetheless, this paper's pure categorization of problem solving was prophetic of mainstream medicine's hubris and incentives: > "Groups, like individuals, tend not to be aware of what they do not know and need to know."

And, > "Such discussions are more likely to suppress symptoms than relieve ailments."

14 hours every day is considered great (don't eat late, skip breakfast), a solid 48 hour fast every month or so is also great. Small human studies, for example, have measured 5x to 10x increases in HGH after 48 to 120 hr fasts respectively. Free steroids, basically; the body repairing itself while not being drowned in food all day every day. Telomeres too!

Totally. Doing sprints on a rower after cutting carbs is a great way to plunge into ketosis -- or anything strenuous for long enough time. Have felt the shift while pushing a lawn mower for a while.

Yes there's a lot of hormonal / circadian rhythm effects at play in the evening and early morning. Additionally, you fast while you sleep, so extending that period before and after (not eating late, plus skipping breakfast) helps; 14 hours is a solid fasting amount if you keep it up every day.

Don't forget electrolytes while fasting / in ketosis (all three: sodium, magnesium, and potassium).

Right, but I imagine most sites will continue to use third-party authorization for passkeys, similar to Okto, Auth0, et al? They'd even be incentived to do so if it meant more granular user profiling -- all alongside third-party guarantees of "real verification", etc.

While better in many ways, broadly speaking this could mean no more throwaway accounts?

Passkeys that require embedding on personal devices like cell phones means direct affiliation with your identity, no? Seems like a shadow benefit to industry is perfect ad targeting across the web.