Back when I was in grad school I set up an HTML/CSS to PDF workflow for making posters. It was surprisingly difficult to find a decent way to render nice-looking web pages with reasonably modern CSS to PDF without having things get cut off or reflowed. I had to use a specific prerelease build of a webkit-based tool to get my template to render correctly. I wonder if there are any better tools in this space these days.
Apart from that, the main issue was the lack of publishing-quality text justification, so I just manually added line breaks where needed to make it look decent. It still beat fiddling around in PowerPoint.