Kicad is the best free EDA I've used and I know many others that use it. The active development and large community make it a no-brainer.
I use Altium professionally ($$$) and I feel like Kicad could cover most of the boards I work on. FYI I've seen a few advanced PCB's done in Kicad successfully - just not sure how much manual calculations/work they had to do.
Kicad + the cheap online PCB vendors are a killer combination.