I think spam is just a nuisance, not a big problem. What is a big problem when hosting providers or your email server are blocking or marking as spam legitimate business communication.
It has happened several times to me that I have not seen a customer's email because it was marked as spam and likewise customers have not seen my email as it was sorted in their spam folder. This is a breakdown of communication that is far worse than spam.
A classic use case that is more likely to be flagged as spam is when a customer submits a request via a web form or on social media and you try to follow up by email. From the receiving email server point of view this is a cold email and in danger of being flagged as spam.