Alice.js - (A Lightweight Independent CSS Engine) 15 years ago
This is just V0.1. We actually hard-coded the check because the code explicitly targets -webkit-* CSS properties internaly. It's also a very small project, and testing for Chrome, iOS and BlackBerry devices already created a lot of work for us. This will definitely improve in future versions and should be a thing of the past by the time we hit our 1.0 milestone (no date on that yet sorry).
As for the comment about design hell :) Yes, agreed. But when i see what has been done in Flash over the years, there has also been incredibly cool looking things done. That's worth that risk imho.
@ldhasson