I had a single terrible experience with dissociatives, to the point that for many many years I had ongoing panic attacks. It was an absolute nightmare for a long time as I was never sure when one might strike.
Without data it’s hard to say how dangerous these drugs are, but they are dangerous. People will pipe in with how you need the right setting and mindset and on and on, it’s never the drug it’s always the patient. But even if that’s all true, none of that is objectively verifiable, people will still have terrible, life-changing experiences, and we should better understand the rate at which they will before prescribing it broadly.