In my 68K Mac emulator running on modern (or even decade-old) hardware, performance in the traditional sense is less of a concern, but other issues arise. The big ones include CPU-burning loops that wait for a length of time or for an interrupt-decremented counter to reach zero, as well as invalid memory accesses (which I've made crash — no NULL deref for you).
We considered creating a plugin that fixed all these things, it would have been hard to maintain, in the end we travelled around to the people who made these apps and talked them through their problems
Since talking to developers is no longer an option, I actually do write "Such-and-such Tune-up" extensions that patch applications dynamically to make them run better (or at all) in Advanced Mac Substitute, or even Mac OS itself.