Ask HN: Technologies to create a brand new JavaScript application? 11 years ago
May I suggest Meteor JS https://www.meteor.com/
It is powered by NodeJS but abstracts it away.
MeteorJS gets you up and running fairly quickly. Deployment isn't too complicated using Meteor Up (MUP). That being said, I have not built a MeteorJS app that has scaled to millions of users - only smaller webapps.
Good luck and have fun with it ^_^