getoffmycase

I click the comments on Reddit to read the full text of the article copied and pasted instead of clicking on the actual link and dealing with the website at the other end.

You can order them super cheap and in bulk from a variety of retailers. Ranging from simple toy things to rolls of it

This is in OKC, not Tulsa. Tulsans have plenty excitement with the opening of the atrociously bacteria infected Zink Lake running through the middle of the city: https://experience.arcgis.com/experience/d1473cd55d8d40e48c4...

I basically don’t use anything outside of tidyverse or base R because of the package dependency issues.

The entire testing system they describe feels like something I can strive towards too. They make you want their solution because it offers a way of life and thinking and doing like you've never experienced before

What are the proper qualifications to criticize evolution?

The fundamentals of biology are not difficult to grasp. Evolution, DNA -> RNA -> Protein, basic cell signalling, etc are all really easy to grasp with just the tiniest bit of effort. There's really no place for bad analogies, especially such a misleading one.

Sorry to bite your head off, but the reason that I'm passionate about this topic is, and I'm not joking, young earth Creationism. An analogy like the grandparent is something simple to grasp by many people, and then the Creationists can quickly turn around and say, "Well you see how biology is like a computer; somebody built a computer; therefore, God created us in six days, 6000 years ago."

If I had a nickel for every terrible biology to computer processes analogy I saw on this website since joining, I’d probably have enough money to buy a beer. Which is what I feel I need after I see something like this.

Biology does not act like a computer. You cannot reduce biology to an operating system

Honestly the major pain point is that the grad student that wrote the package you need is no longer maintaining it because they’ve graduated. Also the code they wrote sucks, but whatever.

I’m wary of software engineers coming over the bioinformatics because they never have the domain expertise required to make meaningful contributions, and yet many think they know everything.

There is literally a world of biology (text)books that describe the process of evolution and how life came to be. I would recommend finding a syllabus at a local college for a biology class, getting the textbook second hand and then reading it

I am currently in a run playing rapid 5|5 because I found myself consistently running out of time in longer time controls. To me, improving at rapid is making significant progress in my overall chess abilities. I developed a better understanding of end games and openings , so that I can spend more time being careful in the middle game. Recently I noticed that I don’t run out of time in Rapid, and that’s progress to me, regardless of my ELO

Put a DSLR in the freezer with a long exposure time.[1] Instant cosmic ray detector. [1] https://www.reddit.com/r/astrophotography/comments/m1w4wv/i_...

Small correction: this is the same drug as the one already approved by the UK.

I disagree. I think that proteomics is useful without spatial information because it captures a snapshot of cell state, or tissue state rather, of signaling networks via PTMs along with abundance measurements. If you don’t have spatial orientation, you at least have temporal information.

I think increasing the yield of MS2 scans to PSMs specifically by dealing with spectra containing PTMs and chimeric spectra will further enable deeper understanding of cell signaling. Additionally, the targeted analysis of specific sub-proteomes using real time search, using GoDig from the Gygi lab for example, also seems very promising.

Plus, there’s large industry efforts using proteomics as a drug screening tool, an application that doesn’t require spatial resolution of anything. Specifically groups are looking for protein expression knockdown, but it’s not too far a stretch to look for pathway perturbations using real time search and careful controls.

There is nothing that I can think of. The tools of the trade are mass spectrometers, most dominantly right now the high end Orbitraps and the TIMS-TOF. If you’re interested in instrumentation I can send you some resources.

There’s a few good reviews I can send you if you’re interested. Let me know, I’d be happy to connect.

Technically two or three of the silver line buses are also considered to be subway, too. I believe SL1, SL2, and SL3. They’re subway fare and they go underground at some point

I thought northern MI was full of trolls (people that live under the bridge to the yoopers)

Yeah I primarily use DataGrip and Rider. I use DataSpell with the R plugin, and Pycharm is a godsend when I have to program something in python. I don’t do it very often and really appreciate pycharm’s ease of use.

Rider is a great, lightweight alternative to visual studio 2022. And honestly DataGrip is perfection and shouldn’t be touched.

Starting from a problem and making a solution requires that you understand both your problem domain and the domain of the solution very well. Much harder than taking a hammer and hitting everything that kind of looks like a nail

Apple Maps isn’t great, but in Boston, MA, Google maps has been an awful experience. I think the most egregious issue Ive experienced is that Google tries to adjust your location to the route it has planned, rather than displaying your location on a map. It’s also unable to deal with the tunnels, and re-routes because it thinks I’m on surface streets if going too slow.

Finally, it’s instructions just flat out aren’t good for dealing with the complexity of Boston’s intersections.

I’ve had more luck with Apple Maps but mostly I just navigate by pre planning my routes using a map

The fire truck had lights and sirens on according to updated articles, so the Cruise vehicle would be at fault

Biotech and drug discovery is inherently gambling. Most May tank, but some have the potential to 10-20x. Traditionally their IPOs allowed them to spread the risk out broadly amongst the public. Then they somehow became stupidly overvalued in 2020-2021

I’d be happy to chat offline. Your current work and my current work I think share a lot of similarity. My GitHub is avcarr2.

From one proteomics person to another, what tools are you using? I can see needing snakemake for something like proteogenomics (our lab published a tool in that area) or DIA cause that pipeline can get a little complex. But for run of the mill stuff, as long as I have CLIs, I don’t really find myself needing anything beyond a basic batch file.

Before you wonder why I don’t know that, I do top-down software development primarily and also maintain and upgrade my lab’s search engine, MetaMorpheus.

There is a potent cholesterol raising compound, cafestol, in coffee that is removed when the it is filtered with paper.

The image where she found the duplications in the microscopy image demonstrates an absolutely unreal pattern recognition ability. I knew of her, but I hadn’t previously seen this essay

American Prometheus is the first real book I read as a 5th grader doing a book report on a scientist. It inspired me to become a scientist myself.

Undergrad researchers are typically shielded from all of the bullshit that goes on behind the scenes because they aren’t in lab 40+ hours a week. I know, personally, of 5 separate 16-18 year old kids that have been a part of academic labs.

They have all been professors kids or friends of professors kids

Quick edit: I’ll also add that PIs project one face to prospective students and “outreach” students, like a high schooler is. Additionally, adding a high schooler to your lab gets you points for scientific outreach, which can help with certain grant submissions.

I am an analytical chemistry PhD student about to turn in my dissertation, and I also have had no thorough education in signal processing, and had to teach myself what I know. It's really a shame because I do know a ton about the phenomena that produce signals that we analyze, but very little about the signals themselves. Kind of a deficiency in my education I suppose.

According to a talk I heard from a VC, the bulk of investments return very little, several may 2x to 5x, a few may 5x, and one will 15-20x or greater.

They’re looking for a 10+% return on the entire portfolio.