HN user

cjbgkagh

5,874 karma

eliza101011@gmail.com

Posts0
Comments2,505
View on HN
No posts found.

I think it’s a socially acceptable costly signal for communicating that power, less about the power itself. Perhaps a different culture could have settled on a humiliation ritual. Either way it has to be costly otherwise it won’t be seen as a true signal though it is likely possible to find a more efficient costly signal.

(Not GP) I would, a lot of my work now is at the edge of what Fable is capable of and even then only with a lot of hand holding. Opus has no chance. I’ve been using Sol and that has been better than Fable in that it needs much less handholding and is much less likely to burn its tokens spinning its wheels.

They made search worse on purpose to make more money, then tried to gaslight everyone by blaming SEO. It was getting rather hard to find things with it, I would have to explain to people that search wasn’t always this bad. I have negative sympathy for them.

I call it 3 scams in a trench coat pretending to be a real economy. Though obviously there are more than 3 going. You kinda have to be in one of the grifts in order to pay the costs of the others, like work in military contracting in order to pay for healthcare. That’s why crackdowns on fraud, collusion, and other such grifts, rackets, and anticompetitive actions in the US is doomed to fail, those who benefit from it tend to be the most reliable political donors. It’s hard to go after one and not go after the others and that would upset a lot of politically powerful people, this results in an armistice and not going after any.

I actually do, I completely and elegantly solved a core problem of my niche industry that had been plaguing it for over 40 years. I was already planning on doing it and had put aside 4-6 months to do it. I did it with the help of AI in 3 days. The AI couldn't do it on it's own I had to walk it through the process piece by piece, and it kept trying to avoid doing as I asked by lying to me, so I kept chastising it. It eventually relented and it worked. There was a deep theoretical underpinning which I believe was beyond AIs ability to originate but once it understood what I was doing it was great at the mechanics of it. I've tried to explain similar ideas to humans with much less success.

Now I've massively expanded my scope and I'm still worried I'll run out of work by the end of the year. It's so much fun. Previously I would have to try to convince people with money to fund such applied research and often the strings they'd attach would doom it to failure. I was worried I would never have the resources to test out my ideas in my lifetime and I would die not knowing if they were any good, and since one of the big ones has already worked I'm pretty stoked.

I wonder if the people getting 10x productivity gains are spending less time on HN and more time tending to their agents. Personally I now spend so much time productively arguing with agents that it feels like an utter waste of effort arguing with humans, if people can't see the value in LLMs by now I'm not sure what I could say to change their minds.

That reaction could very much be dose dependent. I think those in most need of the effect start out very hypersensitive to it and that reaction could easily obscure any benefits.

I use Modafinil and Amitryptiline as a rather unorthodox method for treating dysautonomia which seems to be an intrinsic precursor to ME/CFS, at least in my case where I have hEDS from a number of TNXB variants.

My overall theory is that a combination of anxiety disorders (genetic inability to ameliorate stress) pushes me into a Sympathetic state and keeps me there to the point that cytokines (or some undiscovered small molecule) are created by the immune system to knock me out of that state as a backup to other mechanisms that have stopped working. So I studied some psychopharmacology to design a drug combo that wouldn’t override the autonomic state so I could both work with my natural rhythms (using weaker ligands) and increase the magnitude of the swings so that I could spend enough time in the Parasympathetic state to obviate the need for the immune system backup. I take a lower dose of Modafinil (100mg started and stayed at this dose no apparent tolerance build) and am genetically very sensitive to caffeine so that and one coffee is enough to get me amped for the entire day, but I need amitryptiline to bring me back down to sleep (started as 25mg and many years later I’m at 125mg due to increasing tolerance). I do want to bring down my reliance on amitryptiline but I’m working crazy hours and figure I can wait to titrate down my dose later. I’ve been at this same dose for a year now so it’s at least not getting any worse).

I started on an extremely small dose and worked up very slowly because I predicted and did in-fact have hyperactivity to it. I got gastroparisis and the associated huge amount of vomiting, couldn’t eat for the first few weeks. But slowly over the course of 3-6 months I was having few and fewer bad days. I take a bunch of other meds as well but this one is one of the most effective. I also do LDN, Amitryptiline, Modafinil, TUDCA, DIM, low dose of TRT and Ipamorelin/ModGRF. I eat the absolute minimum in sugar, one meal per day, and that is usually a large kale salad. The Modafinil / Amitryptiline is probably the most effective treatment I’ve tried, followed by the semaglutide, then the TRT/hGH peptides.

No, if that’s all it was then ME/CFS would be a cake walk and it isn’t. I have such a crazy restrictive diet and have had for a long time that one of my issues was being kicked out of doctor's offices for looking too healthy. The diet is necessary but not sufficient.

I get mine on the black market, 50c/mg for semaglutide, $3 per month at my current rate of usage. I’ve been on it for years, I was getting gray market at $12/mg for 3 years before RFK clamped down on that market. It’s exactly the same stuff (for me, no guarantee for others), had it tested in a lab and as the side effect profile is on point. It massively relieved my ME/CFS, back when I started there was no way I could have gotten a prescription let alone insurance to cover it.

It is a rare side effect, I helped a bunch of people (~50) get LDN, primarily for LongCovid, and only one other had a similar ‘too much energy’ effect and both of us have multiple TNXB SNPs and a very similar rare personality profile. I think the brain is so starved for dopamine at that point that it becomes hyper sensitive. I do miss the extra high energy but I also know that isn’t maintainable and I try to err on the side of caution.

I’ve had ME/CFS my whole life but the third covid vaccine shot sent me to new lows, to the point LDN just wasn’t cutting it anymore. These days I take a combo of modafinil in the morning and amitryptiline at night. And low dose ozempic has been super helpful as well. I was researching GLP1As prior to the current craze because I was worried about hyper sensitivity so I waited for more data before trying, I started at 1/100th the normal starting dose and still got temporary gastroparesis. These days I take a more regular dose of 1mg/wk but it also seems that my body has largely normalized as the hypersensitivities have worn off. Probably a good sign that I’ve successfully addressed actual deficiencies.

That is what makes it cult like and not a full on cult, there is a lot of truth to what he says. The problems is when the conclusions are extrapolated out to absurdity - it’s hard for me to listen to it. I didn’t take sufficient notes to give a proper recount here and it’s a bit too much work for me to go through it again.