In 2003 I started experiencing wrist pain when using mouse. As it became unbearable, this is what I did: - Went to see a doctor, without any results - Switched mouse from right to left hand. It took around 10 days to come to speed with left hand. - Right wrist continued to be painful as soon as I get a mouse with it. It took around 4 years to be able to take mouse with it without pain.
Recently I started to use mouse with right hand again and problem didn't reappear yet.
I am also more aware of the way how I handle the mouse - try not to use a ot of force when handling mouse. Switch to wireless mouse, for example.