As someone with a Bachelors in Biochemistry and Computer Science, my sense is that the frustration comes not from the lack of transferable skills per se, but that there is not a lot of self determination and opportunity.
The challenge with big bio science is that you need access to tremendous resources to do anything interesting. Labs are expensive, equipment is expensive so you need to get access through the gates before you can do anything. Once you are in a lab, you have to manage aligned agendas between your PI and yourself to move forward. Large bioscience is about resource acquisition. The same is probably true of high energy particle physicists. The lack of jobs and positions is a side effect that a lab just needs a lot of resources. Ecologist and other field biologists seem less miserable. You can do low cost field work as a field biologist.
Computing as another commented, in biostatistics allows a degree of able to do the work directly. And in that area costs are getting cheaper. As a computer person, I can do things without needing to get permission. Bio is still the most interesting thing, hey we've never engineered life, open question. But the age of gentleman biology is long gone.
There is a lot of good molecular bio to be done, but there are few opportunities due to exogenous factors. Half the effort is getting the opportunity and that is definitely miserable.