aCameronhuff

He’s gotten a lot of press attention and it’s great, but it’s not something new. The researchers who do GBM work are always looking at developments in the parallel tracks of other cancers. It’s not really the case that they haven’t looked at melanoma work. That’s sort of a news spin on the nature of this work. There’s always cross-pollination because the genetic underpinnings of cancers are almost always related. For example, IDH inhibitors (the most recent advancements for glioma patients) are relevant for several kinds of cancer, not just gliomas.

You’re welcome. I’m the author if you have any questions.

Unfortunately this is true, and there’s no near-term treatment that might change this outcome. There’s some treatments for slowing it down but there’s no proof of anyone being cured by any experimental method. There’s great progress being made and thousands of people working on paths to a cure but we’re still early days for some diseases.

Here’s a summary of all of the current treatments and near future treatments for GBM/glioma: https://docs.google.com/file/d/1kTa3eamaL91Smjh9r_0CYv5OYFX4....

This is as complete a list as you’ll find, written in plain English, with citations for every part of it. Slightly out of date but there hasn’t been much that’s new and different since last year. Vorasidenib was approved recently in USA and it’s the most effective IDH inhibitor - worth reading more about.

The document is focussed on glioma but there’s a lot of GBM research. Unfortunately the short answer is that there is no cure and there is treatment that might be a cure under development. There are treatments that slow the course, and the patient’s doctors know all of them and they will recommend what’s best. This is an area of medicine that is hard for amateurs to learn about, and a neurooncologist has decades more training than their patients. The reality is this is a horrible disease that currently has no cure - and the treatments that work are all complex medicines prescribed by specialists.

Decentral | Full-time | ONSITE | Toronto, Canada | Market Salary | https://www.jaxx.io | Backend & Frontend

Our company makes a cryptocurrency wallet called Jaxx (https://jaxx.io/) that has many hundreds of thousands of users around the world. The founder & CEO is Ethereum co-founder Anthony Di Iorio.

We're looking for skilled developers who want to take our product to the next level for version 2. You don't have to be knowledgeable about cryptocurrency but you should be interested in building the decentralized future & eager to learn.

Our team is about 25, with ~20 people in the Toronto headquarters. We'll soon be moving to a new five floor office space and we have a number of projects planned that need creative thinkers to build out.

Tech stack: -AWS -Node.js -MongoDB + MySQL -TypeScript -Git

Helpful: -Vue/Angular/React -AWS networking knowledge -Strong in source control (Git) and other professional software developer tools -Able to apply best practices for testing -Team-minded and open to learning -Able to act as mentor to others -Understand how to create scalable systems

How to apply? careers@decentral.ca.

Mention HN and you'll be fast-tracked. We're just looking for Toronto people. If you're really excited to work with us and think you're really exceptional but not in Toronto feel free to contact us, but know that we're aiming to build out the Toronto local team right now. My email is addison@decentral.ca.

Decentral | Full-time | ONSITE | Toronto, Canada | Market Salary | https://www.jaxx.io | Backend & Frontend

Our company makes a cryptocurrency wallet called Jaxx (https://jaxx.io/) that has many hundreds of thousands of users around the world. The founder & CEO is Ethereum co-founder Anthony Di Iorio.

We're looking for skilled developers who want to take our product to the next level for version 2. You don't have to be knowledgeable about cryptocurrency but you should be interested in building the decentralized future & eager to learn.

Our team is about 25, with ~20 people in the Toronto headquarters. We'll soon be moving to a new five floor office space and we have a number of projects planned that need creative thinkers to build out.

Tech stack: -AWS -Node.js -MongoDB + MySQL -TypeScript -Git

Helpful: -Vue/Angular/React -AWS networking knowledge -Strong in source control (Git) and other professional software developer tools -Able to apply best practices for testing -Team-minded and open to learning -Able to act as mentor to others -Understand how to create scalable systems

How to apply? careers@decentral.ca. Mention HN and you'll be fast-tracked. We're just looking for Toronto people. If you're really excited to work with us and think you're really exceptional but not in Toronto feel free to contact us, but know that we're aiming to build out the Toronto local team right now.

Canada