Scientists reverse autism-like symptoms in mice

https://www.psypost.org/scientists-reverse-autism-like-symptoms-in-mice-by-repairing-shortened-nerve-cell-structures/

by amichail • 22 days ago

12 13 22 days ago

psypost.org

hoppp5• 22 days ago

What if I don't find it abnormal and enjoy my autism?

The only thing I dislike is that people will attack me because they misread my body language.

Apparently having a resting bitch face is an unwritten crime in society.

I would be worried that by rewriting my brain's wiring to socialize better I lose my hyperfocus or heightened perception because you can't have it all.

Either you evolve to analyse other people or the world around, not both.

bjourne2• 22 days ago

What does your comment have to do with the article?

hoppp5• 22 days ago

Its a comment with a subjective autistic experience and the article is about reversing autistic conditions

moi2388• 22 days ago

Either you evolve to analyse other people or the world around, not both.

What makes you think people can’t do both?

hoppp5• 21 days ago

You can do both always, but what you are better at is determined by neuroplasticity.

A bottom up thinker will analyze the environment very thoroughly.

A top down thinker will react to social cues faster, while skipping over the details.

You can do both but one will be effortful and the other effortless, depending on your neurological makeup.

In the context of social interaction, a top down thinker can become irritated against bottom up thinkers due to processing speed difference and mirroring difficulties.

People can't just switch processing styles easily and they show it during normal interactions.

almostjazz• 22 days ago

Just a reminder that there is nothing new about reversing autism-like symptoms in mice.

And that autism in humans is not well-defined.

And that whether or not varying severities of autism should be perceived as a disorder or condition in need of a cure does not have a consensus among experts.

hoppp5• 22 days ago

Autism is a very broad term that is no longer descriptive enough of the underlying condition.

Some people are really struggling while others are thriving.

It can involve thousands of genes and other factors.

Unless they invent better descriptions for the wide variety of conditions discussions are extremely generalized at best.

BigGreenJorts• 22 days ago

I recall sometime last year they were looking at being able to categorize 3 broad subcategories of autism that likely have separate causes and different levels of disability and symptoms. Depending on how true that is, it's possible we can isolate the axies of traits that are debilitating.

question4HN• 22 days ago

Just a reminder that there is nothing new about reversing autism-like symptoms in mice.

As posted here 14 years ago:

Autism-like behaviors reversed in mice https://news.ycombinator.com/item?id=4816907

bjourne2• 22 days ago

If I understand the research correctly, they have created viral code which runs the moral equivalent of

    update brain set syn_strength ×= 1.1 
    where src_region=med_prefront_ctx and dst_region=dorsal_raphae

in the brains of mice without affecting any surrounding tissue. Pretty impressive. Or actually, since the update remained dormant until activated, more like a trigger: create trigger fix_brain update brain ... when brain_juice_z > 0.8

mrguyorama• 22 days ago

we report significant structural and functional deficits in the AIS within a clinically relevant ASD mouse model harboring a 15q11-13 duplication (15q dup).

This is specifically about a type of autism seemingly caused by a very rare genetic disorder.

This will happen more and more as we uncover more specific causes of things like Autism and ADHD. The disorders will continue to be broken into more specific diseases that we can actually treat.

I wonder what it would feel like? I have generalized anxiety and ADHD, and treating those is such an interesting experience. You can feel how your brain is different in the way it works. But at the same time it's subtle in other ways.

Scientists reverse autism-like symptoms in mice

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