Ask HN: Finding it near impossible to get job interviews, help?

I'm a self-taught mid-20s dev; I landed my first proper developer job at a local (Louisville, KY) startup nearly 2 years ago, we went under fairly recently and besides a bit of freelancing, I've been out of work since. I've found it nearly impossible to hunt down openings locally, so my search has been aimed at the usual big cities. Trouble is, I've barely managed to get responses at all, much less interviews. I understand that being inexperienced and out of town doesn't help my case much; but what could I be doing to attract more interviews (and hopefully jobs)? Am I crazy for even trying for out-of-town at my exp. level? How should I be finding openings around here?

FWIW: this last job was a mix of devops, backend, and mobile; I consider myself fairly language and tech agnostic (we used Ruby, C#, and Java; I use Clojure where possible in my personal hacking)