High-fat diet impairs memory by autophagic-lysosomal dysfunction in Drosophila

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011818

by PaulHoule • 10 months ago

25 13 10 months ago

journals.plos.org

DaveZale• 10 months ago

yes. Search pubmed.gov for some excellent reviews on high saturated fat diets and the blood brain barrier.

cellis• 10 months ago

Are they trying to imply that high fat diets in humans similarly affect brain autophagy? That seems like quite the causal stretch given the vastly more complex metabolic architecture of humans.

trallnag3• 10 months ago

I'm don't see where the authors are making this implication.

cosmin800• 10 months ago

I was expecting a mouse at least. Aren't these insects supposed to be feeding on fruits? Why feed them ribeyes?

trallnag3• 10 months ago

Coconut oil. And fruit flies do need fats for proper development.

No1• 10 months ago

Whenever you see a "high-fat diet" study, you can usually translate that to "hypercaloric diet" study, and this one is no exception.

One fly food was 8% glucose (.308 kcal/g) and the other was 8% glucose + 20% coconut oil (.308 kcal/g + .7136 kcal/g = 1.0216 kcal/g) leaving the high-fat arm with 332% of the caloric density of the standard fly food diet. The discrepancy clouds how much of the observed effect is due to the coconut oil, and how much is due to the difference in caloric density.

I looked into how well fruit flies self-regulate caloric consumption, but all that I could find was related to carbohydrates and protein. It would seem that fruit flies don't typically eat much in the way of fats, presenting another confounder in the results.

pcthrowaway• 10 months ago

In fruit flies

profstasiak• 10 months ago

who cares? I can eat a ribeye steak and feel my hippocampus waking up from a glucose-infested coma. And no fruit fly will convince me otherwise!

ceving• 10 months ago

If you eat more protein than you need, the excess is converted into glucose.

teytra• 10 months ago

But note that it actually takes energy to break down the protein.

If you eat 100 kcal protein your body burns 20-30 kcal to process it. And you will feel more satiated than with the same amount of carbs.

trallnag3• 10 months ago

I wonder if there is a difference based on the length of the ingested fatty acids. Currently I ingest around 90 grams of MCTs per day.

hshdhdhj44442• 10 months ago

The goal of this study is to suggest a mechanism for a high fat diet and memory issues, not to prove that the link exists which has been shown elsewhere.

High-fat diet impairs memory by autophagic-lysosomal dysfunction in Drosophila

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