Ask HN: Chrome won't browse to site on same subnet. Safari will, ICMP works

Weird one that seems to only have begun within the last few Chrome updates:

My IP: 10.78.16.20

I want to open an app at 10.78.16.30. Chrome tells me ERR_ADDRESS_UNREACHABLE.

Yet Safari can open it. ICMP, SSH works.

What gives?

Trying to search for an answer to this is painful between all the "check your network, check your modem, restart Chrome" useless answers.