A human embryonic limb cell atlas resolved in space and time

https://www.nature.com/articles/s41586-023-06806-x

by wjb3 • 3 years ago

66 10 3 years ago

nature.com

bookofjoe• 3 years ago

previously: https://news.ycombinator.com/item?id=38559128

qup• 3 years ago

I'll save everyone a click: there's zero comments in the previous submission, which was by the commenter.

sebmellen2• 3 years ago

OK, I guess I'll be the first to ask. What does this mean?

tetris113• 3 years ago

A cell atlas is a collection of annotated cell types, clustered by similar gene expression. The proximity of the cell types as shown by the projection infer lineage, meaning one cell type begat another. By taking samples at various time points, you can unearth more and more (rare) cell types transitioning from cell type to another, giving you lineage specification from stem cells all the way down to the mature cell types of your tissue of choice. Here they went out on a limb and went with limb.

sebmellen2• 3 years ago

Wow, that's pretty cool. Do we have a complete lineage for any other mature tissue/cell types?

RecycledEle• 3 years ago

Just imagine if, instead of reading HN, you had been a specimen in the experiments that led to this atlas.

A human embryonic limb cell atlas resolved in space and time

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