Chemically induced reprogramming to reverse cellular aging

https://www.aging-us.com/article/204896/text

by g42gregory • 3 years ago

54 17 3 years ago

darkclouds4• 3 years ago

"The accumulation of senescent cells with age promotes inflammation and generates additional reactive oxygen species (ROS), both locally and across the organism, contributing to a broad range of age-related diseases, from macular degeneration, to increased blood pressure, to metabolic dysregulation"

Thats an understatement, some liken the damage caused by senescent cells to be as and more damaging than cancer cells but without the cell multiplication, mainly because apoptosis doesnt happen and the immune system cant destroy them, they just hang around damaging surrounding healthy cells.

jareklupinski• 3 years ago

this is why i have started donating blood as rapidly as I can

like a car engine getting its oil changed helps clear out the accumulated 'cruft' from the liquid medium, but even better, since my body will just produce fresh "oil" (blood) from the snacks they give at the end

win/win for everyone

darkclouds4• 3 years ago

I've seen those reports that having organs or blood from a younger person can help rejuvenate the body. I wouldnt do it personally, I'd rather get the diet right which I think can overcome most of the environmental problems we face today and increase our life spans.

I only found out a few weeks ago our stem cell count starts declining in our twenties. I think trying to reverse that is key to a longer healthier life but drugs like filgrastim which is used to harvest stem cells for leukaemia is not the answer.

Likewise as kids our bones are packed full of red bone marrow, but when we hit puberty the non flat bones start changing to yellow bone marrow which is much like the stem cells you get from adipose tissue aka fat tissue, and they are a little less predictable.

Vit K1 reportedly reverses senescent cells, so maybe we should be eating our greens every day. Vegetarians are also reported to live longer so there might be some truth in it, but there are other chemicals in our diet which are also important.

arpowers• 3 years ago

Summarized with AI:

- The study demonstrates that certain molecules can effectively 'reverse' the aging process in cells without changing their core identity.

- A system called NCC has been used as a successful indicator of biological age reversal, paving the way for broader research into rejuvenation factors.

- An important element, OSK, helps improve aging cell health, potentially leading to treatment strategies for aging-related diseases.

- Various interventions have shown to reduce signs of aging in cells by changing the way genes are expressed. Six specific treatments significantly decreased both biological and chronological age of cells.

- The study found that early stages of cellular 'reprogramming' can rejuvenate cells without making them behave like stem cells. One particular treatment, VC6TF, showed the most potent rejuvenation effects.

- Further research is required to understand how this cellular 'age reversal' works and how it compares to other similar processes, particularly one triggered by the OSK element.

- Certain compounds play a big role in the process of cellular rejuvenation by affecting the way cells express their genetic material.

- Safety tests in animals are crucial before these rejuvenation treatments can be tested in humans, especially to check for potential signs of abnormal tissue growth or cancer.

anigbrowl• 3 years ago

Don't do this. IT's akin to posting a list of search results from Google. Anyone who wants an AI summary can generate their own.

O1111OOO• 3 years ago

Thank you for the summary!

I'm not heavily invested in AI (machine learning) and don't have tools to do X or Y. This saved me a lot of time and broke down the (dense) article nicely for me.

inglor_cz3• 3 years ago

In a related development, a LA-based team around Dr. Gregory Fahy is looking for alternative ways how to rejuvenate thymus in humans.

They have been experimenting with thymus rejuvenation in volunteers for years and it seems that most people experience both subjective and measurable improvements in their overall health that are somewhat consistent with systemic rejuvenation.

But the current protocol uses Human Growth Hormone and they want to find out if something less expensive and with fewer potential side effects can be used.

parhamn• 3 years ago

Do you know what the protocol is? I looked online but there seemed to be a ton of feels-fake type marketing material and videos I'd need to sift through.

HGH/Somatropin is pretty readily available in LatAM countries (~$100 per 2 week dose).

inglor_cz3• 3 years ago

Look up the TRIIM and TRIIM-X trials.

darkclouds4• 3 years ago

500mg of nicotinic acid on an empty stomach will spike HGH well above what you see when you go through puberty, most people dont like the sunburn effect which you get when taking it, but you wont get cheaper than that if you need want HGH. Word of warning, nicotinic acid will increase your chances of osteomalacia.

thimkerbell• 3 years ago

This is building off their previous research results which got the world's opposite of attention, being published in late March of 2020. https://med.stanford.edu/news/all-news/2020/03/old-human-cel...

Turing_Machine3• 3 years ago

Yep, though that's gene therapy rather than drug therapy (which is what this paper claims).

With respect to the previous gene therapy results, Sinclair posted on Twitter that human trials are in the preparation stage..

inglor_cz3• 3 years ago

Yamanaka factors are promising, but at the same time rather dangerous, as one of them (cMyc) is a powerful oncogene.

Hence, the search for safer alternatives. What the Yamanaka factors do is not just rejuvenation, but also de-differentiation of cells, with the latter being undesirable in clinical settings. (Though desirable for stem cell production.) It is possible that these two effects can be separated and rejuvenation can be achieved without de-differentiation.

perilunar• 3 years ago

Twitter thread by Prof. David Sinclair announcing the paper: https://twitter.com/davidasinclair/status/167917867074373224...

(Surprised this hasn't hit the homepage yet — it's incredible news)

Chemically induced reprogramming to reverse cellular aging

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