Incidence and risk factors of myocarditis following Covid-19 vaccination

https://www.bmj.com/content/378/bmj-2021-069445

by MuchoMaas • 4 years ago

3 9 4 years ago

jleyank4• 4 years ago

Such studies should compare the risk to the covid-19 infection itself vs. the risk to vaccination and infection to the risk of vaccination. Whatever comes from vaccination is present in (far) greater supply during infection. Other than the lipid particle and whatever is used to deliver the mRNA.

And given the various non-mRNA vaccines, there should be a non-random difference shown between the various alternatives, as they stimulate an immune response via different mechanisms. Hell, maybe the problem comes from the immune response itself... If that's the case, there should be some correlation of effect vs. intensity of response. This has already been shown wrt cytokine storm, but this is discussing other forms or results of inflammation.

MuchoMaas4• 4 years ago

Such studies should compare the risk to the covid-19 infection itself vs. the risk to vaccination and infection to the risk of vaccination.

I'm not sure why that comparison would be relevant, since vaccination does not zero out the risk of infection or developing myocarditis from that infection. The risks are cumulative, not mutually exclusive.

It also doesn't seem clear to me that spike protein exposure is necessarily higher from infection than vaccination, as you assert. Do you have any studies that show this? The only comparisons I've seen have been between the levels of anti-spike antibodies, which are much higher following vaccination.

Age stratification is also an important consideration here. A large Israeli study found no increase in incidence of myocarditis among ~200,000 unvaccinated individuals who contracted SARS-CoV-2: https://euroweeklynews.com/2022/07/08/no-increase-myocarditi...

jleyank4• 4 years ago

If the risks are cumulative, I would expect such studies will show that. If they're not, the risks would relate directly to which of 3 conditions are present. And I have to assume that there are (far) more spike proteins created in an infection than due to the mRNA vaccine as there is no reproduction in the latter case - it only expresses what it can while the mRNA "instructions" last. In the case of infections, viruses covered in spike proteins result.

didibus• 4 years ago

Incidence of myocarditis is probably the highest in males aged 12-29 years and more likely with Moderna than with Pfizer mRNA vaccines; longer dosing intervals might be beneficial
Most cases of myocarditis are mild and self-limiting, but data on children and some severe cases are limited

It seems we still don't know the root-cause for why this can happen, but at least it appears to be mostly a rare and mild side-effect.

Incidence and risk factors of myocarditis following Covid-19 vaccination

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