Air pollution particles in young brains linked to Alzheimer's damage

https://www.theguardian.com/environment/2020/oct/06/air-pollution-particles-in-young-brains-linked-to-alzheimers-damage

by bookofjoe • 6 years ago

3 5 6 years ago

bookofjoe2• 6 years ago

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal

https://www.sciencedirect.com/science/article/abs/pii/S00139...

JPLeRouzic2• 6 years ago

I only read the abstract, but it seems to me that because they found iron and other metals in the brain, they infer it is there because of air pollution.

I am not a scientist but there are metals in the brain, at least iron from the blood stream, copper and zinc because they stabilize proteins shaping. Iron can be detected with MRI.

What makes them think there is a causal link between air pollution and metals in the brain? I am missing something from the abstract?

bookofjoe2• 6 years ago

From the Guardian article:

There is already good statistical evidence that higher exposure to air pollution increases rates of neurodegenerative diseases, but the significance of the new study is that it shows a possible physical mechanism by which the damage is done.
The researchers found abundant pollution nanoparticles in the brainstems of 186 young people from Mexico City who had died suddenly between the ages of 11 months and 27 years. They are likely to have reached the brain after being inhaled into the bloodstream, or via the nose or gut.
The nanoparticles were closely associated with abnormal proteins that are hallmarks of Alzheimer’s, Parkinson’s and motor neurone disease. The aberrant proteins were not seen in the brains of age-matched people from less polluted areas, they said.
"It is terrifying because, even in the infants, there is neuropathology in the brain stem," said Prof Barbara Maher, at Lancaster University, UK, and part of the research team. "We can’t prove causality so far, but how could you expect these nanoparticles containing those metal species to sit inert and harmless inside critical cells of the brain? That's the smoking gun – it seriously looks as if those nanoparticles are firing the bullets that are causing the observed neurodegenerative damage."
Maher said the work provides hypotheses that could now be tested. For example, brain stem damage would affect the movement control and gait of young people and this should correlate with pollution exposure if the nanoparticles are the cause.
The causes of neurodegenerative disease are complex and not fully understood. “There’s definitely going to be genetic factors and there’s highly likely to be other neurotoxicants,” said Maher. “But the thing that’s special about air pollution is how pervasively people are exposed to it. I don’t think that human systems have developed any defence mechanisms to protect themselves from nanoparticles.”
She said it was important to study children as they have not experienced other factors associated with dementia such as alcohol consumption: “So they become the canaries in the coalmine.”
The research was led by Lilian Calderón-Garcidueña at the University of Montana, US, and is published in the journal Environmental Research. It found the metal-rich nanoparticles matched the shape and chemical composition of those produced by traffic, through combustion and braking friction, and which are abundant in the air of Mexico City and many other cities.
Prof Louise Serpell, at the University of Sussex, UK, said the nanoparticles were a plausible cause of the brain damage, but that there was not enough evidence that nanoparticles could cause the neurodegenerative diseases: “There are many other likely causes for neurodegenerative diseases.” But she said: “Our environmental exposure to pollution and pathogens is probably very important in triggering disease.”
Jordi Sunyer, doctor in medicine and surgery at the University of Barcelona, said animal experiments had shown that inhaled nanoparticles could reach the brain and cause damage, but he said inflammatory chemicals triggered by air pollution in the lung could also reach the brain.

Air pollution particles in young brains linked to Alzheimer's damage

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