Feline coronavirus drugs inhibit SARS-CoV-2 main protease

https://www.nature.com/articles/s41467-020-18096-2

by sapsan • 6 years ago

12 1 6 years ago

nature.com

phobosanomaly• 6 years ago

From what I can tell GC376 is preclinical in cats, but it's been around for a while?

"When given to younger kittens, GC376 interfered with the development of permanent teeth."

https://www.avma.org/javma-news/2020-01-15/fip-drugs-continu...

A subsequent compound was developed called GS-441524 that showed greater efficacy, and has been making its way out of the Chinese black market to desperate cat owners, which vets aren't thrilled about.

https://ccah.vetmed.ucdavis.edu/cats/resources/general-felin...

I smell the next hydroxychloroquine with a future run on black-market Chinese GS-441524.

Edit: From Wikipedia - "The public health advocacy group, Public Citizen, in an open letter urged the DHHS and Gilead to investigate GS-441524 for the treatment of COVID-19, suggesting that GILEAD was not doing so for financial motives related to the longer intellectual property lifespan of Remdesivir."

Feline coronavirus drugs inhibit SARS-CoV-2 main protease

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