MSI-1436 stimulates regeneration of heart and multiple other tissues

https://www.nature.com/articles/s41536-017-0008-1

by nirmalc • 7 years ago

116 26 7 years ago

nature.com

AstralStorm• 7 years ago

Hopefully this works too in Phase 2 and Phase 3 trials. Looks promising.

And doesn't get patented to hell with insane pricing.

rootw0rm3• 7 years ago

patents don't mean shit. if it's safe, effective, and profitable I'll be able to custom order it soon enough.

brian_herman__• 7 years ago

How and where do you do this?!

jokowueu3• 7 years ago

Dep nding on how complex the molecule is sometimes they won't even be able to make it . More than the half the group buys on that specific longevity forum failed

jksmith• 7 years ago

Yep, looking into it.

jz_• 7 years ago

The latest news on the compound is from April 2019: https://www.eurekalert.org/pub_releases/2019-04/nb-nba041019...

If anyone is interested in a talk by one of the authors (Kevin Strange), he goes into the history of the compound here: https://www.youtube.com/watch?v=6aAr5pKW9Dw

For progress on similar lines of tech, this is a good site: https://www.lifespan.io/the-rejuvenation-roadmap/

bitwize• 7 years ago

...in zebrafish. Settle down, the answer to all your health problems is still fasting.

chrisco255• 7 years ago

"It is particularly noteworthy that MSI-1436 stimulates tissue regeneration in both zebrafish and adult mice, two widely divergent species that are separated by approximately 450 million years of evolution."

Also paper explained that the drug had been applied in Phase 1 clinical trials with humans as a treatment for diabetes and obesity.

"Importantly, the doses we have shown to be effective in stimulating tissue regeneration are 5–50-times lower than the maximum well-tolerated human dose."

taneq• 7 years ago

Wait till the mice hear about this one!

aussieguy1234• 7 years ago

Zebrafish != Humans

sheeshkebab• 7 years ago

It passed phase 1 trial in humans as well.

ur-whale• 7 years ago

Legitimate question : how hard would it be to synthesize in one's garage?

kirykl• 7 years ago

I wonder how this would affect patients whom have had cardiac ablation, possibly causing unwanted cellular re-growth

defterGoose• 7 years ago

ITT: People who read nothing past the first paragraph saying, 'Yeah, but only in zebrafish ppl'

MSI-1436 stimulates regeneration of heart and multiple other tissues

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