NAD+ could regulate aging, may explain rejuvenation

http://science.sciencemag.org/content/355/6331/1312

by mkempe • 9 years ago

53 10 9 years ago

science.sciencemag.org

mkempe4• 9 years ago

Here is the description via Harvard: "Critical step found in DNA repair, cellular aging" [1]

[1] http://news.harvard.edu/gazette/story/2017/03/harvard-scient...

mkempe4• 9 years ago

The high-dosage NMN (boosting production of NAD+) fed to mice via drinking water appears to be 300 mg/kg of bodyweight/day.

How much would it cost to produce 5 grams per day (adjusted for a couple of humans)? and how could a regular, motivated (software) engineer learn to do it?

Edit: adjusted the dose to 1/12th for mice-to-human adjustment, we're looking at 5g NMN/day for a couple (not 50g).

cwisecarver2• 9 years ago

Related: https://www.elysiumhealth.com

I've been taking this for about 6 months. Haven't noticed much other than better sleep, easier to wake upon time feeling refreshed.

mkempe4• 9 years ago

That's NR, not NMN. Also, the daily Elysium dose of NR is 500mg, much less in proportion to body weight than what was fed to the mice in this Harvard study.

Added: Thanks to jclos below. The human-mouse-equivalent NMN dose would be 1/12th, 25mg/kg of bodyweight/day.

cwisecarver2• 9 years ago

It does boost production of NDA+ though, right?

jclos• 9 years ago

Keep in mind that there is no 1:1 mapping between mg/kg/day for mice and for humans due to difference in metabolism. http://www.ergo-log.com/calculatethehumandosage.html gives a couple of useful formulas to calculate the actual dosage for humans and it's much more reasonable.

caycep• 9 years ago

that being said, NAD is so ubiquitous that I can't imagine it is the only factor. It's may be more akin to saying if you use Chevron gas with techron vs. Arco gas, that your engine may last another 5,000 miles or something. But it doesn't address primary causes of engine failure based on design, engineering, etc.

fiter• 9 years ago

I don't think a car analogy is apt because a car isn't self-repairing like many biological processes.

NAD+ could regulate aging, may explain rejuvenation

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