Ask HN: Which Amazon S3 region should I use if latency is not a consideration?

I am about to upload a number of things to Amazon S3, including a static website and some file backups. Access to the former will mostly be via CDN, and access to the latter should be infrequent. Therefore in neither case is latency a significant consideration, and hence neither is physical location.

Which S3 region would you recommend I use in this situation? Is there a "main" or "default" region which people generally use for this sort of data? Or should I just choose the nearest? Or one of the cheapest?

It seems to me that us-east-1 (N. Virginia) comes closest to being the "main" region - would you recommend using us-east-1 for this reason? Or would you recommend against it, especially after this week's outage?